Health Benefits of Naringin     September, 2008

Flavonoids are widely recognized as naturally occurring
antioxidants. Naringin (NG) is one of the flavonoid
components in citrus fruits such as grapefruit. Hydrogen
peroxide (H2O2) causes cytotoxicity through oxidative
stress and apoptosis. Kannno S and co-workers from
Tohoku Pharmaceutical University, Japan, found that
naringin reduced hydrogen peroxide induced cytotoxicity.
It also chromatin condensation and DNA damage. [1]
Martin MJ and co-workers, from Universidad de Sevilla,
España, found the the gastroprotective properties of
naringin on and the involvement of endogenous
prostaglandins in mucosal injury produced by absolute
ethanol. [2] Preliminary studies have also shown that
naringin has a potent lipid-lowering effect and antioxidant
capacity in high-cholesterol diet fed animals. [3,4]

[1] Kanno S, et al, Effects of naringin on hydrogen peroxide-induced cytotoxicity
and apoptosis in P388 cells. J Pharmacol Sci. 2003 Jun;92(2):166-70. [2] Martín
MJ, Antiulcer effect of naringin on gastric lesions induced by ethanol in rats.
Pharmacology. 1994 Sep;49(3):144-50. [3] Jung UJ, et al, Naringin
supplementation lowers plasma lipids and enhances erythrocyte antioxidant
enzyme activities in hypercholesterolemic subjects. Clin Nutr. 2003
Dec;22(6):561-8. [4] Kim HJ, et al, Naringin alters the cholesterol biosynthesis and
antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed
condition. Life Sci. 2004 Feb 13;74(13):1621-34.

ALL RIGHTS RESERVED 2008. This article can not be used as medical
advice. Please, consult with your doctor before using any drug and
supplement products.