Health Benefits of Hesperidin     
Hesperidin, a bioflavonoid, is an abundant and inexpensive by-product of
Citrus cultivation. A deficiency of this substance in the diet has been linked
with abnormal capillary leakiness as well as pain in the extremities
causing aches, weakness and night leg cramps. No signs of toxicity have
been observed with the normal intake of hesperidin or related compounds.
Both hesperidin and its aglycone hesperetin have been reported to
possess a wide range of pharmacological properties. [1]

Uehara M, a professor at Tokyo University of Agriculture, suggested that
hesiperidin might have potential benefits in preventing capillary
impermeability, inflammation, infection and cancer in his review article. [2]
He further suggested that hesperidin could also regulates hepatic
cholesterol synthesis by inhibiting the activity of 3-hydroxy-3-methlyglutaryl
coenzyme A (HMG-CoA) reductase. He also found hesperidin inhibited
bone loss the animals with lowering serum and hepatic cholesterol. He
believes hesperidin may act on bone by the same mechanism as that of
statins. [2]

Administration of benzo(a)pyrene to mice resulted in increased lipid
peroxides, lung specific tumor marker carcinoembryonic antigen and
serum marker enzymes aryl hydrocarbon hydroxylase and other
biomarkers. Indian researchers found hesperidin supplementation
significantly attenuated these alterations thereby showing potent
anticancer effect in lung cancer. [3]

Korean researchers found hesperidin could prevent liver injury in rats from
gamma-irradiation. [4] While, Yamamoto M and co-workers from Kao
Corporation, Tochigi, Japan demonstrated the blood pressure lowering
effect of hesperidin in rats through nitric oxide-mediated vasodilation. [5]

However, its major side effect maybe its interaction with some drugs.
Uesawa Y and co-workers from Meiji Pharmaceutical University, Japan,
found concomitant administration of orange juice or hesperidin with
celiprolol significantly decreased the area under the plasma
concentration-time curve (AUC) by 74% and 75%, respectively, compared
with control. [6]

ALL RIGHTS RESERVED 2008. This article can not be used as medical advice. Please,
consult with your doctor before using any drug and supplement products.

[1] Garg A Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res. 2001
Dec;15(8):655-69. [2] Uehara M Prevention of osteoporosis by foods and dietary supplements. Hesperidin and
bone metabolism Clin Calcium. 2006 Oct;16(10):1669-76. [3] Kamaraj S, et al Antioxidant and anticancer
efficacy of hesperidin in benzo(a)pyrene induced lung carcinogenesis in mice. Invest New Drugs. 2008 Aug
13. [4] Pradeep K et al, Hesperidin a flavanoglycone protects against gamma-irradiation induced
hepatocellular damage and oxidative stress in Sprague-Dawley rats. Eur J Pharmacol. 2008 Jun
10;587(1-3):273-80. Epub 2008 Apr 4. [5] Yamamoto M et al, Short-term effects of glucosyl hesperidin and
hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. J Nutr Sci
Vitaminol (Tokyo). 2008 Feb;54(1):95-8. [6] Hesperidin in orange juice reduces the absorption of celiprolol
in rats Biopharm Drug Dispos. 2008 Apr;29(3):185-8