Shitake Mushroom benefits, shiitake mushroom health benefits
September 22, 2011
Reishi Mushroom Benefits
Reishi [Lingzhi, Ganoderma lucidum] mushroom is a popular supplement with an impressive array of reputed health
benefits.  Reishi mushroom is the highest grade of mushroom in the world of fungi. Some herbalists call reishi
mushroom as "The King of All Herbs" or "The Miraculous King of Herbs. Reishi mushroom is also called as Lingzhi in
China, and Youngchi in Korea. Reishi mushrooms may benefit people with high blood pressure and may also benefit
people suffered from altitude sickness, chronic hepatitis B, glomerulosclerosis, diabetes and cancer. [
Reishi Mushroom
This website discusses the benefits and side effects of various supplements, herbs and drug products. Different people may experience different
side effects and benefits of a product. You are encouraged to report adverse side effects to FDA, its website is, or report the
adverse side effects to the manufacturer, you should be able to find the contact information on the label.

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preparing this document and the information provided herein is believed to be accurate. The information is not intended to be a substitute for
professional medical advice. It is important to seek the advice of a physician about any medical condition or symptom or the benefits and side
effects of a supplement or a drug product. Finally, please, do not transfer the article to other website. Thank you. ALL RIGHTS RESERVED.
Other Medicinal Mushrooms
Medicinal mushrooms are mushrooms that are used as treatments for diseases. Other medicinal mushrooms include:
Maitake Mushroom Benefits
Maitake mushroom [Grifola frondosa] is an edible fungus. It has a large fruiting body and overlapping caps. Similar to
other medicinal mushrooms, there are evidence that it may benefit people at risk of cancers. A bioactive metabolite
produced by maitake mushroom showed activities against human carcinoma cells (Hep 3B, Hep G2, HeLa, CL1-1) and
normal human lung fibroblast. Maitake mushroom was also shown to improved lipid and glucose profiles in animals.
Maitake Mushroom Benefits]
Shiitake Mushroom
Other names: Japanese mushroom, シイタケ, Black Forest mushroom, golden oak mushroom, oakwood mushroom,
fragrant mushroom 香菇; Lentinus edodes, Lentinula edodes and Agaricus edodes. [1, 2]

The shiitake mushroom is an edible mushroom native to East Asia, and being dried and exported to many countries. It
has two Chinese variant names for high grades of shiitake are dōnggū (冬菇, "winter mushroom") and huāgū (花菇,
"flower mushroom"). Shitake mushroom is used as a remedy for upper respiratory diseases, poor blood circulation, liver
trouble, exhaustion and weakness, and to boost qi, or life energy, as well as prevention of premature aging. [2]

Shiitake mushroom benefits
Shiitake mushroom has two important extracts - active hexose correlated compound (AHCC) and lentinan. AHCC, an α-
glucan-rich compound, is popularly used as supplement by cancer patients in Japan. [3] Clinical study has shown
AHCC may benefit patients with hepatocellular carcinoma. [4,5] AHCC has also been shown to enhance immune
function. [6,7] Lentinan also shows anti-cancer activities, it may benefit people suffered from various types of cancers.
According to, lentinan is currently used in Australia as part of a pharmacological blend to suppress
cancer cell proliferation and to promote proliferation of peripheral blood lymphocytes. [2]

Shiitake mushroom benefits - liver protection
Shiitake mushroom extract showed protection of liver cells from paracetamol at a dose of 200 mg/kg was administered
to the paracetamol treated mice for seven days. [8]

The mycelia of the Shiitake mushroom can be cultured in solid medium containing lignin, and the hot-water extracts is
commercially available as a nutritional supplement in Japan. During the cultivation, phenolic compounds, such as
syringic acid and vanillic acid, were produced by lignin-degrading peroxidase secreted from Shiitake mushroom
mycelia. These compounds have radical scavenging activity. In a mice-study, liver was injuried by CCl4. And, this four
weeks of CCl(4) treatment caused a sufficiently excessive deposition of collagen fibrils. The intravenous administration
of syringic acid and vanillic acid significantly decreased the levels of the transaminases. An examination of liver
sections revealed that syringic acid and vanillic acid obviously suppressed collagen accumulation and significantly
decreased the hepatic hydroxyproline content, which is the quantitative marker of fibrosis. [9]

Shiitake mushroom benefits - lipid profiles and vascular conditions
Shiitake mushroom has hypocholesterolemic activities and alters phospholipid and fatty acid metabolism in rats. [12] In
a study, 32 rabbits were fed with 1.0% cholesterol for 8 weeks, then divided into groups and given 1) 1.0% cholesterol
for over 8 weeks (control), 2) 1.0% cholesterol and 1.0% shiitake mushroom extract for over 8 weeks, 3) 1.0%
cholesterol and 2.0% shiitake mushroom extracts for over 8 weeks, and 4) 1.0% cholesterol and 4.0% shiitake
mushroom for over 8 weeks. Decreases in surface involvement of were significant in the 1% shiitake mushroom groups
compared with the control. The atherosclerotic index was also significantly decreased in the shiitake mushroom groups
compared with the control. Thus, shiitake mushroom may inhibit atherosclerotic development in rabbit aorta and
potentially benefit people at risk of atherosclerosis. [13]

Shiitake mushroom benefits - on diabetes
The hypoglycemic effect of an exo-polymer produced from a submerged mycelial culture of shiitake mushroom was
demonstrated in streptozotocin-induced diabetic rats. The administration of the exo-polymer (200 mg/kg BW) reduced
the plasma glucose level by as much as 21.5%, and increased plasma insulin by 22.1% as compared to the control
group. It also lowered the plasma total cholesterol and triglyceride levels by 25.1 and 44.5%, respectively. [14]

Shiitake Mushroom Side Effects
Contact dermatitis has been reported.  A 52-year-old man who developed a generalized pruritic papulovesicular
eruption 2 weeks after daily consumption of uncooked shiitake mushrooms. [10] Eosinophilic oesophagitis developed
after intake of shiitake mushroom was also reported. [11] While, shiitake mushroom side effects can also include
stomach discomfort, blood abnormalities, and skin swelling (15)
[1] Shiitake Mushroom, The American Cancer Society website, September 21, 2011  [2] Shiitake,, September 21, 2011.
[3] Hyodo I, et al (April 2005). "Nationwide survey on complementary and alternative medicine in cancer patients in Japan". Journal of
Clinical Oncology 23 (12): 2645–54.
AHCC Benefits: [4, 5] Cowawintaweewat S, et al (March 2006). "Prognostic improvement of patients
with advanced liver cancer after active hexose correlated compound (AHCC) treatment". Asian Pacific Journal of Allergy and Immunology
24 (1): 33–45. Matsui Y, et al (July 2002). "Improved prognosis of postoperative hepatocellular carcinoma patients when treated with
functional foods: a prospective cohort study". Journal of Hepatology 37 (1): 78–86. [6, 7] Gao Y, et al (October 2006). "Active hexose
correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses". Cancer
Immunology, Immunotherapy 55 (10): 1258–66. Aviles H, et al (October 2004). "Active hexose correlated compound enhances the
immune function of mice in the hindlimb-unloading model of spaceflight conditions". Journal of Applied Physiology 97 (4): 1437–44. [8]
Itoh A., Hepatoprotective effect of syringic acid and vanillic acid on CCl4-induced liver injury. Biol Pharm Bull. 2010;33(6):983-7. [9] Kopp
T, et al, Systemic allergic contact dermatitis due to consumption of raw shiitake mushroom. Clin Exp Dermatol. 2009 Dec;34(8):e910-3.
[11] Goikoetxea MJ et al, Food allergy to Shiitake (Lentinus edodes) manifested as oesophageal symptoms in a patient with probable
eosinophilic oesophagitis. Allergol Immunopathol (Madr). 2009 Nov-Dec;37(6):333-4. [12] Shimada Y, et al, Effects of Lentinus edodes
on fatty acid and molecular species profiles of phosphatidylcholine in rats fed different levels of corn oil. Biosci Biotechnol Biochem.
2002 Aug;66(8):1759-63. [13] Yamada T, et al, Effects of Lentinus edodes mycelia on dietary-induced atherosclerotic involvement in
rabbit aorta. J Atheroscler Thromb. 2002;9(3):149-56. [14] Yang BK, et al, Hypoglycemic effect of a Lentinus edodes exo-polymer
produced from a submerged mycelial culture. Biosci Biotechnol Biochem. 2002 May;66(5):937-42. (15} (09-22-2011)  )