Gotu kola benefits
gotu kola reviews and gotu kola dosage updated on October 23, 2011
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Gotu kola may have benefits of increasing antioxidant enzymes. Oral treatment with crude methanol extract of gotu
kola for 14 days was found to increase the anti-oxidant enzymes, like superoxide dismutase, catalase and
glutathione peroxidase, and anti-oxidants like glutathione and ascorbic acid decreased in lymphoma-bearing mice.
[10] In another study, gotu Kola rendered radioprotection to DNA and membranes against radiation exposure, both
in vitro and in vivo. Administration of the extract was possibly able to prevent a radiation-induced decline in
antioxidant enzyme levels. [A2]

Gotu kola shows benefits on patients suffered from diabetes. Gotu Kola tablets, dosage 60 mg twice daily for 12
months, is effective in improving the microcirculation in diabetic microangiopathy and neuropathy, Treatment was
well tolerated; no
side effects were reported. [Angiology. 2001 Oct;52 Suppl 2:S27-31]

Thirty patients with
diabetic microangiopathy were treated for 6 months with total triterpenic fraction of Centella
asiatica (
dosage 60 mg twice daily). After six months, there was a significant improvement of microcirculatory
parameter in patients treated with gotu kola. [Angiology. 2001 Oct;52 Suppl 2:S49-54.]

Gotu kola may benefit people suffered from venous insufficiency and hypertension. In a study of 94 patients
suffered from venous insufficiency of the lower limbs, researchers found improvements in symptoms of heaviness in
the lower limbs and edema in the group treated with titrated extract of gotu kola

Total triterpenic fraction of gotu kola may benefit people with chronic venous hypertension and it may protect the
venous endothelium. The triterpenic fraction is active on connective tissue modulation, it improves the synthesis of
collagen and other tissue proteins by modulating the action of fibroblasts in the vein wall, and stimulates collagen
remodeling in and around the venous wall. Thus, it may have benefits in venous hypertension and edema or
protection against the deterioration of microcirculation (due to diabetic microangiopathy), but more studies are
needed to confirm this thought/finding.

Gotu Kola has shown health benefits on wound healing. Human skin fibroblast culture studies suggest guta kola may
benefit people with wounds. Its wound healing action is found to be related to collagen and fibronectin.

In 1999, a study showed that topical asiaticoside application twice daily for 7 days to excision-type cutaneous
wounds in rats led to increased enzymatic and non-enzymatic antioxidants, namely superoxide dismutase (35%),
catalase (67%), glutathione peroxidase (49%), vitamin E (77%) and ascorbic acid (36%) in newly formed tissues.
These enhanced induction of antioxidant levels may further suggest the benefits of guta kola on wound healing.
On the other hand, asiaticoside was found to induce cell-cycle progression, proliferation and collagen synthesis in
human dermal fibroblasts. This may be another way how guta kola benefit the wound healing process. Again, clinical
studies are needed to support this potential benefits.

In a study of rats suffered from gastric ulcer, the healing effect (the reduction of the ulcer size) of gotu kola water
extract/asiaticoside was dose-dependent. The healing effect seems to be related to NO synthesis inhibition. [17]
Furthermore, gotu kola juice was found to increase mucin secretion in rats, this may offer protection from ethanol-,
aspirin, cold-restraint stress- and pyloric ligation. [18]On the other hand, gotu kola water extract and asiaticoside
was found to upregulate the expression of basic fibroblast growth factor in ulcer tissue of rats suffered from gastric
ulcers. [19]

Gotu kola may have benefits against virus. Aqueous extract of gotu kola was found to be  high effective on inhibition
of HSV-II. [16]

Gotu Kola is believed to have many benefits on patients suffered from cancers; at least, it enhanced the anti-tumor
activities of vincristine in cell studies [17]

A study demonstrated that asiatic acid (gotu kola) could  induce apoptosis of SK-MEL-2 human melanoma cells via
generation of ROS, alteration of Bax/Bcl-2 ratio and activation of caspase-3, but p53-independent. Consequently,  
asiatic acid (gotu kola)  may have potential health benefits on human skin cancer. [18]

A Japanese scientist prepared methanol extract from the aerial parts of gotu kola.  This extract contained ursolic
acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic
acid, corosolic acid, and rosmarinic acid. They found that all these compounds from gotu kola had antiproliferative
activities against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma
(B16F10) cells was estimated. [19]

Yoshida M et al, Fukuoka University, Japan prepared methanol extract from the aerial parts of gotu kola.  This gotu
kola extract contained ursolic acid lactone, ursolic acid, pomolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid,
3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. They found that all these compounds had
antiproliferative activities against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and
murine melanoma (B16F10) cells was estimated. [20]

Gotu kola may benefit people at risk of heart and liver diseases. Gnanapragasam A et al, University of Madras,
India, found that pre-co-treatment with gotu kola (200 mg/kg of body wt/oral) extract significantly prevented the
alterations of the levels of serum makers LDH, CPK, GOT and GPT for myocardial damage as well as several
important antioxidant enzymes such as SOD, CAT, GPx, GST during the treatment of adriamycin. [21]

Ming ZJ et al, Suzhou University, Jiangsu, found that total glucosides of gotu kola could improve the liver functions
(in terms of serum ALT, AST, HA) as well as liver fibrosis during the treatment with dimethylnitrosamine in animal
studies. [22]

How does gotu benefit conditions like Alzheimer's Disease? Lee MK et al, Seoul National University, Korea, modified
the chemical structure of asiatic acid (from gotu kola) and obtained 36 derivatives and they found three derivatives
significantly mitigated the neurotoxicity induced by glutamate in their screening system. The neuroprotective
activities of these 3 derivatives appeared to be more powerful than that of asiatic acid itself. These 3 derivatives
significantly attenuated decreases in the levels of glutathione, glutathione peroxidase and other enzymes, which
participate in the cellular defense mechanisms blunting oxidative stress. Furthermore, they also significantly reduced
the overproduction of NO induced by glutamate. [Res Commun Mol Pathol Pharmacol. 2000 Jul-Aug;108(1-2):75-86]

Considering, oxidative stress or an impaired endogenous anti-oxidant mechanism is an important factor for
Alzheimer's disease and Intracerebroventricular streptozotocin (IS) in rats has been likened to sporadic Alzheimer's
disease in humans, Veerendra Kumar MH et al, All India Institute of Medical Sciences, India, studied the effect of an
aqueous extract of gotu kola on IS- rats. They found that rats treated with gotu kola showed a dose-dependent
increase in cognitive behaviour. They concluded that aqueous extract of C. asiatica is effective in preventing the
cognitive deficits, as well as the oxidative stress, caused by Intracerebroventricular (i.c.v.) streptozotocin in rats.
[Clin Exp Pharmacol Physiol. 2003 May-Jun;30(5-6):336-42]

Researchers from Michigan State University showed that the neuroprotective properties of asiatic acid (a key
ingredient from Gotu Kola) might be mediated in part through decreased blood-brain barrier permeability and
reduction in mitochondrial injury in a mouse model of permanent cerebral ischemia. Asiatic acid significantly reduced
the infarct volume by 60% at day 1 and by 26% at day 7 postischemia and improved neurological outcome at 24 hr
postischemia. [A1]

Gotu kola extract altered amyloid beta pathology in the brains of PSAPP mice and modulating components of the
oxidative stress response that has been implicated in the neurodegenerative changes that occur with Alzheimer's
disease. [A4] Thus, gotu kola may benefit people suffered from Alzheimer's disease, if its effect is reproducible in

Gotu kola may benefit people at risk of radiation. Sharma et al, University of Rajasthan, India, found gotu kola dose
increased the survival time of the mice significantly, when the mice were irradiated with Co 60 gamma radiation
externally. [Phytother Res. 2002 Dec;16(8):785-6]

Joints Gotu kola may also have benefits on people suffered from certain joint issues. Researchers from Centre for
Specialised Nutrition demonstrated that gotu kola fraction was able to inhibit the zymosan-induced cartilage
degradation in vivo without affecting the zymosan-induced inflammatory cell infiltration and joint swelling. [A3]
Gotu kola Herb Reviews
Recent studies demonstrated that Gotu kola herb destroyed cultured tumor cells in the laboratory setting (in vitro),
promoted wound healing and more. This article summarize a few possible gotu kola benefits. Gotu Kola (Centella
asiatica) is a slender, creeping plant that grows mainly in swampy areas of India, Sri Lanka, Madagascara and South
Africa. Because gotu kola's leaves are about the size of an old British penny, people also called it  Indian pennywort,
marsh penny or water pennywort.

Gotu Kola herb was considered as a spiritual herb in Ayurveda and it is used with meditation to revitalize the nerves
and brain cells. In traditional medicine, gotu kola is believed to help develop the crown charka, the energy center at
the top of the head. Gotu Kola is commonly used for "brain elevation". As early as in 1950s, Ratsimamanga AR et al
and Antonelli NS et al reported that gotu kola herb might have benefits on refractory wounds, such as leprosy, lupus
and ulcers.[1-5].  And the key ingredient of gotu kola herb is known to be asiatic acid, a pentacyclic triterpene. [6-9]
Gotu Kola Tea has been claimed to have benefits of enhancing brain and memory functions, treating
Disease and overcoming stress and fatigue by online venders. Unfortunately, these claims have no or very limited
direct scientific support. Clinical studies or at least more animal studies are needed to verify these gotu kola tea
benefits.Some websitesstates that asiaticoside is associated with tumor in an animal study. But an in vitro study
indicates asiaticoside is an anti-tumor agent and enhanced anti-tumor activity of vincristine in the study. [A5]
However, overdosage of gotu kola may cause side effects such as headache, stomach upset, nausea, dizziness, and
extreme drowsiness.
Gotu Kola, Benefits, Side Effects, Cellulite, Hair Loss, Tea
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