| polyoxyethanyl-alpha-tocopheryl sebacate |
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DISEASES. ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD
CONSULT WITH YOUR DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED. DO NOT COPY NOR TRANSFER ARTICLES TO
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Properties
Below its melting point of 25°C, polyoxyethanyl-alpha-tocopheryl sebacate is a
yellow-orange wax. Above 25°C, polyoxyethanyl-alpha-tocopheryl sebacate is a
yellow-orange viscous fluid that dissolves in water, alcohols, dichloromethane and
tetrahydrofuran, but not in hexane. Polyoxyethanyl-alpha-tocopheryl sebacate is
hygroscopic and stable at room temperature in aqueous solution.
In GRN 000202, polyoxyethanyl-alpha-tocopheryl sebacate is intended to be used as a
solubilizer for the dietary ingredient coenzyme Q10 (CoQ10) in dietary supplements.
Manufacturing Process
Polyoxyethanyl-alpha-tocopheryl sebacate is manufactured by two consecutive
esterification reactions under anhydrous conditions in ethylacetate with added
triethylamine. Alpha-tocopherol is first linked to sebacoyl dichloride by esterification at its
hydroxy terminus. The resultant alpha-tocopheryl mono-ester of sebacoyl chloride is
subsequently esterified with PEG (molecular weight (mol. wt.) 600) (PEG600) to form
polyoxyethanyl-alpha-tocopheryl sebacate. Polyoxyethanyl-alpha-tocopheryl sebacateis
subsequently purified using acetonitrile and hexane to remove the major impurity,
di-alpha-tocopheryl-sebacate, which is formed as a by-product of sebacoyl chloride
diester formation with alpha-tocopherol.
Daily Consumption
Zymes, the manufacturer, estimates that the intake of PTS would be limited to 1200
mg/p/day or 20 milligram per kilogram of bodyweight per day (mg/kg bw/day) from the
intended uses.
GRAS Notice No. GRN 000202
SOURCE: FDA website 2010
Below its melting point of 25°C, polyoxyethanyl-alpha-tocopheryl sebacate is a
yellow-orange wax. Above 25°C, polyoxyethanyl-alpha-tocopheryl sebacate is a
yellow-orange viscous fluid that dissolves in water, alcohols, dichloromethane and
tetrahydrofuran, but not in hexane. Polyoxyethanyl-alpha-tocopheryl sebacate is
hygroscopic and stable at room temperature in aqueous solution.
In GRN 000202, polyoxyethanyl-alpha-tocopheryl sebacate is intended to be used as a
solubilizer for the dietary ingredient coenzyme Q10 (CoQ10) in dietary supplements.
Manufacturing Process
Polyoxyethanyl-alpha-tocopheryl sebacate is manufactured by two consecutive
esterification reactions under anhydrous conditions in ethylacetate with added
triethylamine. Alpha-tocopherol is first linked to sebacoyl dichloride by esterification at its
hydroxy terminus. The resultant alpha-tocopheryl mono-ester of sebacoyl chloride is
subsequently esterified with PEG (molecular weight (mol. wt.) 600) (PEG600) to form
polyoxyethanyl-alpha-tocopheryl sebacate. Polyoxyethanyl-alpha-tocopheryl sebacateis
subsequently purified using acetonitrile and hexane to remove the major impurity,
di-alpha-tocopheryl-sebacate, which is formed as a by-product of sebacoyl chloride
diester formation with alpha-tocopherol.
Daily Consumption
Zymes, the manufacturer, estimates that the intake of PTS would be limited to 1200
mg/p/day or 20 milligram per kilogram of bodyweight per day (mg/kg bw/day) from the
intended uses.
GRAS Notice No. GRN 000202
SOURCE: FDA website 2010