Hyaluronic Acid Reviews
Hyaluronic Acid Benefits                   November 2 2011                                                zhion@zhion.com    
The Potential Benefits of Hyluronic Acid
The major potential benefit of hyluronic acid is its support on osteoarthritis, skin conditions such as actinic keratose,
wrinkles and fold. Let's review its potential medical uses-

1. Hyluronic Acid Benefits - Osteoarthritis
Hyaluronan preparations have shown to decrease pain but improve the mobility of patients suffered from knee
osteoarthritis. The improvement in the condition is possibly related to alternations in the synovial fluid viscoelasticity,
cartilage metabolism, and inflammation.

Turkish researchers injected high molecular weight hyaluronic acid (Hylan G-F 20) and low molecular weight hyaluronic
acid (
Orthovisc) to 92 patients suffered from knee osteoarthritis separately at one-week intervals for three weeks.  
Both hyaluronic acid preparations resulted in a pronounced reduction in pain and improved function, without

Roth A et al, Friedrich Schiller University Jena, Germany, treated rats with high molecular weight hyaluronic acid
(1.7X10(6) a; 0.5 mg/dose). They found that a short-term hyaluronic acid treatment could inhibit acute inflammation
and cartilage damage while a long-term hyaluronic acid treatment promote joint swelling, inflammation and cartilage

2. Hyaluronic Acid Benefits - Brain Injury
Tian WM et al, Tsinghua University, China, found hydrogel made of hyaluronic acid-poly-D lysine is compatible to rat
brain tissue as this hydrogel has an open porous structure and its viscoelastric properties are similar to the neural
tissue's. [4]

3. Hyaluronic Acid Benefits - Skin Conditions
Regulatory approval in the USA, Canada and Europe was granted recently for 3% diclofenac in 2.5% HA gel,
Solaraze(R), for the topical treatment of actinic keratoses, which is the third most common
skin complaint in the USA.
The gel is well tolerated, safe and efficacious and provides an attractive, cost-effective alternative to cryoablation,
curettage or dermabrasion, or treatment with 5-fluorouracil. [5]

4. Hyaluronic Acid Benefits - Appearance - Wrinkles and Folds - Anti-aging
This injectable Restylane (hyaluronic acid) gel was approved on March 25, 2005. It is a transparent hyaluronic acid
gel that is injected into facial tissue to smooth wrinkles and folds, especially around the nose and mouth (nasolabial
folds). This hyaluronic acid gel works by temporarily adding volume to facial tissue to restore a smoother appearance
to the face. The effect of this hyaluronic acid gel can last for about 6 months. In a clinical study, most patients needed
one injection of this hyaluronic acid gel to achieve the optimal benefits of wrinkle smoothing; about one-third of patients
needed more than one injection of this hyaluronic acid gel to get a satisfactory result. [6]

Volume loss and muscular hyperactivity are two major components of the aging process that contribute to the
formation of the folds and wrinkles. Tear trough deformity is one of the most difficult depressions to correct surgically.
In a study, 10 patients have had their tears troughs treated with hyaluronic acid gel filler. The filler was introduced by a
serial puncture technique and approximately 0.1 ml was injected at each pass. This pilot study showed that the
treatment of tear trough deformity with hyaluronic acid gel filler was feasible, predictable and effective. But, there were
some side effects, please, review the section of side effects. [15]

5. Hyaluronic Acid Benefits - Bone Defects
1% hyaluronic acid gel associated with a collagen scaffold was found to benefit new bone formation in critical-size
defects in a rat study. [12]

6. Hyaluronic Acid Benefits - Vesicoureteral Reflux
Endoscopic Hyaluronic Acid/Dextranomer Gel Implantation was found to be effective as first-line treatment of
vesicoureteral reflux in children. Serious complications after endoscopic treatment were not noted.[13]

7. Hyaluronic Acid Benefits - Empty Nose Syndrome
Three patients suffering from empty nose syndrome and atrophic rhinitis underwent trial treatment consisting of
submucosal injections of Hyaluronic Acid preparations into the inferior nasal concha and under the mucous membrane
of the septum. As a result of treatment, the patients' symptoms improved for several months and no complications were
recorded. [14]

Hyaluronic Acid Side Effects, Danger, Risk
In geneal, side effects of hyaluronic acid gel include bruising, redness, swelling, pain, tenderness and itching  In
addition, hyaluronic acid gel should not be used in patients suffered from severe allergies. For details, please, review
Hyaluronic Acid Side Effects

Special Applications of Hyaluronic Acid
Hyaluronic acid has been applied in tissue engineering for recellularization and vascularization, e.g. porcine bladder
acellular matrix. [10]

Nanodrug of polyethyleneimine /all-trans retinoic acid conjugates covered with hyaluronic acid (HA) was applied to
treat cancer cells overexpressing P-glycoprotein. [11]

Please note that some of the hyaluronic acid health benefit claims are in lack of clinical studies. Composition and
dosage form also contribute to its side effects and effectiveness. Please, discuss with your doctor before taking or
using any supplement. Thank you.
This website discusses side effects and benefits of a product. You are encouraged to report adverse side
effects to FDA, its website is
www.fda.gov., or report the adverse side effects to the manufacturer, you
should be able to find the contact information on the label.

There are always new information. Please, send me an email (
zhion@zhion.com) to correct my mistake(s).
Reasonable care has been taken in preparing this document and the information provided herein is
believed to be accurate. The information is not intended to be a substitute for professional medical
advice. It is important to seek the advice of a physician about any medical condition or symptom or the
benefits and side effects of a supplement or a drug product. Finally, please, do not transfer the article to
other website. Thank you. ALL RIGHTS RESERVED.
Hyaluronic acid Quick View
Hyaluronic Acid is a polysaccharide composed of alternating molecules of N-acetyl glucosamine and D-glucuronic acid.
It can be found within collagen throughout the body. As the most important space filling substance in the human body.
Hyaluronic Acid holds water to keep collagen hydrated and "youthful". Hyaluronic Acid forms a viscous fluid with
exceptional lubricating properties necessary for the vital functions of many parts of the human body including the skin,
heart valves, aqueous/ vitreous humor of the eye and synovial fluid (joint lubricant). The skin contains over 50% of the
bodies Hyaluronic Acid. Considering that skin is over 70% water and renews itself more readily than most other bodily
tissues. Definitely hyaluronic Acid may have benefits on skin's structure and daily maintenance.

In the past, because of its large molecular weight, the absorption for Hyaluronic Acid in the digestive tract was almost
impossible. However, an enzyme-cleaving technique has been developed to break down Hyaluronic Acid into lower
molecular weight polymers. This allows easy absorption of Hyaluronic Acid when taken orally. Studies have shown that
this lighter Hyaluronic Acid might improve wound healing, facial moisture, and skin smoothness. But its greatest benefit
has been seen in joint function.