Oldenlandia diffusa (Bai Hua She She Cao 白花蛇舌草)

Oldenlandia diffusa benefits - on cancers
From 1992 to 1996, Wong BY from Loma Linda University has published at least five articles on how
Oldenlandia diffusa potentially inhibited the growth of cancer cells, or mutagenesis. [1-5]

In 1999, Japanese researchers noticed that Oldenlandia diffusa weakly stimulated on human lymphocytes
in a vitro study. [6]

In 2001, researchers from Hebei Medical University reported that Oldenlandia diffusa has immuno-
modulating activity and anti-tumor activity in vitro through stimulating the immune system to kill or engulf
tumor cells. [7]

Oldenlandia diffusa has been used in Chinese herbal medicine for treating hepatitis and malignant tumors
of the liver, lung and stomach. Researchers found no antiproliferative effect of the methanol extracts from
O. diffusa, while the chloroform extracts exhibited slightly antiproliferative effects. It is not clear if
Oldenlandia diffusa really has benefit on animals suffered from cancers. [8]

A study conducted by researchers from Kingston University, UK, showed that Oldenlandia diffusa
significantly inhibited the growth of the leukaemic cells (HL60) and induced apoptosis in a cell cycle-
independent fashion, possibly through the induction of genotoxic damage. Preliminary chemical analysis
indicated that a number of compounds appear to be responsible for the cytotoxic action of Oldenlandia
diffusa. [9]

A study conducted by researchers from National University of Singapore shows that the ethanol extract of
the herb effectively evokes cancer cell apoptosis, possibly through burst-mediated caspase activation. [10]

Gupta S, Zhang D, Yi J, Shao J. from St. John's University studied the effect of an aqueous oldenlandia
extract on eight cancer cell lines and one normal cell line. They found the extract exhibited a strong
antiproliferative activity against all cancer cell lines tested. Oral administration of the herbal extract
effectively reduced B16-F10 cell growth in the lungs of C57Bl/j mice with a 70% reduction in lung
metastases without noticeable adverse
side effects. The extract also exhibited minimum toxic effect on
normal pancreatic cells. [11]

Oldenlandia diffusa benefit on inflammation and arthritis.
Ursolic acid is pentacyclic triterpenoic acid that naturally occurs in many plants including Oldenlandia
diffusa. Researchers showed that ursolic treatment (per oral) dose-dependently suppressed zymosan-
induced leucocyte migration and prostaglandin E2 (PGE(2)) production in the air pouch exudates in
animal studies (models of inflammation).
Ursolic acid also dramatically inhibited paw swelling, plasma PGE
(2) production and radiological changes in the joint caused by CFA injection (a model of arthritis). These
studies suggest that ursolic acid may benefit animals especially rats and mice at risk of inflammation and
rheumatoid arthritis. [12]

Oldenlandia diffusa benefit on high cholesterol.
In 2005, Korean researchers found a few compounds in Oldenlandia diffusa and they are an iridoid
glycoside, oldenlandoside III (5); geniposidic acid (1), scandoside (2), feretoside (3), 10-omicron-
benzoylscandoside methyl ester (4), asperulosidic acid (6) and deacetylasperulosidic acid (7).
Compounds 1, 2, and 7 inhibited LDL-oxidation, and showed 63.3+/-2.0, 62.2+/-1.6, and 3.8+/-1.5%
inhibition, respectively, at a concentration of 20 microg/mL. [13]


Researchers from Hong Kong found that the chemical composition of Odenlandiae varies from source to
source, dependent on the habitats. Anyway, the major ingredients of oldenlandiae are asperuloside, E-6-
O-P-coumaroylscandoside methyl ester and E-6-O- P-coumaroylscandoside methyl ester-10-methyl
ether. [14]

In 2007, Zhou YJ et al isolated nine compounds from Odenlandiae and they are 2, 6-dihydroxy-1-methoxy-
3-methylanthraquinone, 2-hydroxy-1-methoxy-3-methylanthraquinone, 2-hydroxy-3-methylanthraquinone,
quercetin-3-O-[2-O-(6-O-E-sinapoyl)-beta-D-glucopyranosyl]-beta-glucopyranoside, quercetin-3-O-[2-O-
(6-O-E-feruloyl)-beta-D-glucopyranosyl]-beta-glucopyranoside, kaempferol-3-O-[2-O-(6-O-E-feruloyl)-
e, quercetin-3-O-(2-O-beta-D-glucop-yranosyl)-beta-D-glucopyranoside (7), rutin and quercertin.

Oldenlandia herbacea benefits - antioxidative activities.
Researchers showed a potent antioxidant activity of methanol and ethyl acetate extracts of the whole
plant of Oldenlandia herbacea in a hydrogen peroxide method. [15]

Popular Oldenlandia
Oldenlandia lancifolia (Schumach.) DC. calycose mille graines
Oldenlandia boscii (DC.) Chapm. Bosc's mille graines

Oldenlandia herbacea side effects
A report says oldenlandia herbacea side effect is noticeable adverse side effects. [11] While,
Oldenlandia herbacea side effects may cause difficulty breathing, rash and itching in the upper
extremities, suggested over the internet.


[1] Wong BY, Lau BH, Teel RW. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of benzo
[a]pyrene 7,8-dihydrodiol and benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide. Cancer Lett. 1992 Feb 29;62(2):123-31. [2]
Wong BY, Lau BH, Tadi PP, Teel RW. Chinese medicinal herbs modulate mutagenesis, DNA binding and metabolism of
aflatoxin B1. Mutat Res. 1992 Jun 1;279(3):209-16. [3] Wong BY, Lau BH, Yamasaki T, Teel RW. Modulation of cytochrome
P-450IA1-mediated mutagenicity, DNA binding and metabolism of benzo[a]pyrene by Chinese medicinal herbs. Cancer
Lett. 1993 Jan 15;68(1):75-82. [4] Wong BY, Lau BH, Yamasaki T, Teel RW. Inhibition of dexamethasone-induced
cytochrome P450-mediated mutagenicity and metabolism of aflatoxin B1 by Chinese medicinal herbs. Eur J Cancer Prev.
1993 Jul;2(4):351-6. [5] Wong BY, Lau BH, Jia TY, Wan CP. Oldenlandia diffusa and Scutellaria barbata augment
macrophage oxidative burst and inhibit tumor growth. Cancer Biother Radiopharm. 1996 Feb;11(1):51-6. [6] Shan BE,
Yoshida Y, Sugiura T, Yamashita U. Stimulating activity of Chinese medicinal herbs on human lymphocytes in vitro. Int J
Immunopharmacol. 1999 Mar;21(3):149-59. [7] Shan BE, Zhang JY, Du XN. Immunomodulatory activity and anti-tumor
activity of Oldenlandia diffusa in vitro Zhongguo Zhong Xi Yi Jie He Za Zhi. 2001 May;21(5):370-4. [8] Liang Z, He M, Fong W,
Jiang Z, Zhao Z. A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs
Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential. Phytomedicine. 2008 Apr;15(4):259-
67. Epub 2008 Mar 12. [9] Willimott S, Barker J, Jones LA, Opara EI. Apoptotic effect of Oldenlandia diffusa on the
leukaemic cell line HL60 and human lymphocytes. J Ethnopharmacol. 2007 Dec 3;114(3):290-9. Epub 2007 Aug 19. [10]
Yadav SK, Lee SC. Evidence for Oldenlandia diffusa-evoked cancer cell apoptosis through superoxide burst and caspase
activation. Zhong Xi Yi Jie He Xue Bao. 2006 Sep;4(5):485-9. [11] Gupta S, Zhang D, Yi J, Shao J. Anticancer activities of
Oldenlandia diffusa. J Herb Pharmacother. 2004;4(1):21-33. [12] Kang SY, Yoon SY, Roh DH, Jeon MJ, Seo HS, Uh DK,
Kwon YB, Kim HW, Han HJ, Lee HJ, Lee JH. The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation
and adjuvant-induced chronic arthritis models. J Pharm Pharmacol. 2008 Oct;60(10):1347-54. [13] Kim DH, Lee HJ, Oh YJ,
Kim MJ, Kim SH, Jeong TS, Baek NI. Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation. Arch Pharm
Res. 2005 Oct;28(10):1156-60. [14] Z, Jiang Z, Ho H, Zhao Z. Comparative analysis of Oldenlandia diffusa and its
substitutes by high performance liquid chromatographic fingerprint and mass spectrometric analysis. Planta Med. 2007
Nov;73(14):1502-8. Epub 2007 Nov 5. [14] Zhou YJ, Wu KS, Zeng GY, Tan JB, Xu KP, Li FS, Tan GS. Studies on
constituents of Oldenlandia diffusa Zhongguo Zhong Yao Za Zhi. 2007 Apr;32(7):590-3. [15] Singaravelu P, Shrishailappa
B, Subban R. In vitro antioxidant activity of Oldenlandia herbacea and isolation of 9,9-dimethyl hexacosane and 23-ethyl-
cholest-23-en-3beta-ol. Nat Prod Res. 2008;22(17):1510-5.
oldenlandia diffusa side effects, oldenlandia diffusa benefits
oldenlandia diffusa cancer, capsules and tea August 17, 2011
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