| Pterostilbene health benefits |
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reference only, it is not a medical advice. All rights reserved. Do not copy this article to
other website or blog.
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grapes. It belongs to the group of phytoalexins, agents produced by plants to fight infections.
Compared to resveratrol, pterostibene has a much better bioavailability. [Cancer Chemother
Pharmacol. 2010 Nov 30] It is believed that it may have health benefits such as anti-cancer, anti-
hypercholesterolemia and anti-hypertriglyceridemia activities, but more pieces of evidence are
needed to support these health claims. And, here we are going to review some recent reports
about its potential health benefits:
Perecko T. and co-workers at Slovak Academy of Sciences assessed the cellular and molecular
effects of pterostilbene on human neutrophils and in cell free systems. They found pterostilbene
possessed comparable antioxidant properties as resveratrol in cell free system. Pterostilbene in
concentrations of 10-100 μM was found to inhibit the activity of human caspase-3 purified enzyme
and did not influence cell viability significantly. [Neuro Endocrinol Lett. 2010 Dec 28;31(Suppl2).]
In an animal study, Macickova T and co-researchers at Slovak Academy of Sciences
demonstrated that pterostilbene has a slight effect on oxidative stress induced biochemical
changes occurring in adjuvant arthritis. [Neuro Endocrinol Lett. 2010 Dec 28;31(Suppl2).]
Pterostilbene may have the benefits of anti-cancer activities for certain cancers. The purified
pterostilbene was found to cause apoptosis in breast (MCF-7) and prostate (PC3) cancer cell
lines. [Toxicol In Vitro. 2010 Jun;24(4):1215-28] Pterostilbene shows an additive inhibitory effect
on breast cancer cells when combined with tamoxifen, most likely from augmented cancer cell
apoptosis. [Am J Surg. 2010 Nov;200(5):577-80.] A study of mouse suggests that pterostilbene is
a novel functional agent capable of preventing inflammation-associated colon tumorigenesis. [J
Agric Food Chem. 2010 Aug 11;58(15):8833-41] Pterostilbene was found to induce autophagy
and apoptosis in sensitive and chemoresistant human bladder cancer cells. [Mol Nutr Food Res.
2010 Dec;54(12):1819-32] In test tubes, pterostibene inhibits pancreatic cancer. [J Gastrointest
Surg. 2010 May;14(5):873-9. Epub 2010 Feb 6.] Colon tumors from pterostilbene-fed animals
showed reduced expression of inflammatory markers as well as nuclear staining for phospho-p65,
a key molecule in the nuclear factor-kappaB pathway. In HT-29 cells, pterostilbene reduced the
protein levels of beta-catenin, cyclin D1 and c-MYC, altered the cellular localization of beta-catenin
and inhibited the phosphorylation of p65. Thus, pterostilbene may suppress colon tumorigenesis
[Carcinogenesis. 2010 Jul;31(7):1272-8.]
Vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of
atherosclerosis and restenosis after angioplasty. Atherosclerosis of the arterial wall leads to high
blood pressure. Park ES and co-workers from Chungbuk National University, Korea, showed
pterostilbene significantly inhibited the DNA synthesis and proliferation of platelet-derived growth
factor(PDGF)-BB-stimulated VSMCs in a concentration-dependent manner. From the study, they
speculated that the inhibition of pterostilbene to the cell proliferation and DNA synthesis of PDGF-
BB-stimulated VSMCs may be mediated by the suppression of Akt kinase. [Vascul Pharmacol.
2010 Jul-Aug;53(1-2):61-7.]
Compared to resveratrol, pterostibene has a much better bioavailability. [Cancer Chemother
Pharmacol. 2010 Nov 30] It is believed that it may have health benefits such as anti-cancer, anti-
hypercholesterolemia and anti-hypertriglyceridemia activities, but more pieces of evidence are
needed to support these health claims. And, here we are going to review some recent reports
about its potential health benefits:
Perecko T. and co-workers at Slovak Academy of Sciences assessed the cellular and molecular
effects of pterostilbene on human neutrophils and in cell free systems. They found pterostilbene
possessed comparable antioxidant properties as resveratrol in cell free system. Pterostilbene in
concentrations of 10-100 μM was found to inhibit the activity of human caspase-3 purified enzyme
and did not influence cell viability significantly. [Neuro Endocrinol Lett. 2010 Dec 28;31(Suppl2).]
In an animal study, Macickova T and co-researchers at Slovak Academy of Sciences
demonstrated that pterostilbene has a slight effect on oxidative stress induced biochemical
changes occurring in adjuvant arthritis. [Neuro Endocrinol Lett. 2010 Dec 28;31(Suppl2).]
Pterostilbene may have the benefits of anti-cancer activities for certain cancers. The purified
pterostilbene was found to cause apoptosis in breast (MCF-7) and prostate (PC3) cancer cell
lines. [Toxicol In Vitro. 2010 Jun;24(4):1215-28] Pterostilbene shows an additive inhibitory effect
on breast cancer cells when combined with tamoxifen, most likely from augmented cancer cell
apoptosis. [Am J Surg. 2010 Nov;200(5):577-80.] A study of mouse suggests that pterostilbene is
a novel functional agent capable of preventing inflammation-associated colon tumorigenesis. [J
Agric Food Chem. 2010 Aug 11;58(15):8833-41] Pterostilbene was found to induce autophagy
and apoptosis in sensitive and chemoresistant human bladder cancer cells. [Mol Nutr Food Res.
2010 Dec;54(12):1819-32] In test tubes, pterostibene inhibits pancreatic cancer. [J Gastrointest
Surg. 2010 May;14(5):873-9. Epub 2010 Feb 6.] Colon tumors from pterostilbene-fed animals
showed reduced expression of inflammatory markers as well as nuclear staining for phospho-p65,
a key molecule in the nuclear factor-kappaB pathway. In HT-29 cells, pterostilbene reduced the
protein levels of beta-catenin, cyclin D1 and c-MYC, altered the cellular localization of beta-catenin
and inhibited the phosphorylation of p65. Thus, pterostilbene may suppress colon tumorigenesis
[Carcinogenesis. 2010 Jul;31(7):1272-8.]
Vascular smooth muscle cells (VSMCs) play an important role in the pathogenesis of
atherosclerosis and restenosis after angioplasty. Atherosclerosis of the arterial wall leads to high
blood pressure. Park ES and co-workers from Chungbuk National University, Korea, showed
pterostilbene significantly inhibited the DNA synthesis and proliferation of platelet-derived growth
factor(PDGF)-BB-stimulated VSMCs in a concentration-dependent manner. From the study, they
speculated that the inhibition of pterostilbene to the cell proliferation and DNA synthesis of PDGF-
BB-stimulated VSMCs may be mediated by the suppression of Akt kinase. [Vascul Pharmacol.
2010 Jul-Aug;53(1-2):61-7.]
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Herbal / Dietary Supplements / Foods that may lower the risk of certain types of cancer: Avocados
Banana, Bitter Melon, Brown Seaweed, Capsicum, Cauliflower, Celery, Chlorophyll, Cordyceps, Curcumin,
Dandelion, Ellagic acid, Oldenlandia, Falcarinol, Fenugreek, Feverfew, Fish Oil, Forskolin, Galangal, Garlic,
Gotu Kola, Green Tea, Grape Seed Extract, Honokiol, Orange, Isothiocyanates, Linseed Oil, Limes, Lycopene,
Maitake, Milk Thistle, Onion, Peony, Phellinus, Quercetin, Pterostibene, Pycnogenol, Reishi, Rhubarb, Saffron,
Stinging Nettle, Sweet Potatoes, and more.
Drugs listed in this website for chemotherapy:
Xeloda, Avastin, Tykerb,
Herbal / Dietary Supplements / Foods that may lower the risk of certain types of cancer: Avocados
Banana, Bitter Melon, Brown Seaweed, Capsicum, Cauliflower, Celery, Chlorophyll, Cordyceps, Curcumin,
Dandelion, Ellagic acid, Oldenlandia, Falcarinol, Fenugreek, Feverfew, Fish Oil, Forskolin, Galangal, Garlic,
Gotu Kola, Green Tea, Grape Seed Extract, Honokiol, Orange, Isothiocyanates, Linseed Oil, Limes, Lycopene,
Maitake, Milk Thistle, Onion, Peony, Phellinus, Quercetin, Pterostibene, Pycnogenol, Reishi, Rhubarb, Saffron,
Stinging Nettle, Sweet Potatoes, and more.
Drugs listed in this website for chemotherapy:
Xeloda, Avastin, Tykerb,