Bladderwrack side effects, bladderwrack benefits
bladderwrack extract & tea, uses, weight loss and cellulite December 22, 2011
Bladderwrack Reviews [Fucus vesiculosus, related to Kelp]
Bladderwrack (Bladder Wrack, Fucus vesiculosus) is a rockweed or seaweed having forked, brownish-green branches with gas-filled bladders.
[1]Bladderwrack (Bladder Wrack) can be found on the coasts of the North Sea, the western Baltic Sea,  the Atlantic and Pacific Oceans and it  is
also a common food in Japan.
Bladderwrack Safety Issues, Warning, Interactions and Side Effects
Bladderwrack is possible safe for most healthy subjects at low doses, but high doses of bladderwrack may worsen or
cause thyroid problems. Prolonged high doses of bladderwrack is linked with goiter or even increased risk of thyroid
cancer.

Bladderwrack Side Effects
Iodine can help only for the type of hypothyroidism caused by iodine deficiency. If your iodine levels are not low, taking
extra amounts of iodine may lead to hypothyroidism or hyperthyroidism. Please, also understand that levels of iodine
can vary widely among bladderwrack products. [11] Bladderwrack extract preparations may worsen acne and decrease
iron absorption. [12] Finally, Bladderwrack like other sea plants, can concentrate toxic heavy metals such as arsenic
from the surrounding sea water. One case of kidney failure was reported, because the bladderwrack product used
contained a high heavy metal content. [13-15] Some people use seaweeds as food. In general, the side effects of
bladderwrack are mild or even unnoticeable at recommended dosages.

Bladderwrack - Drug Interaction
Since bladderwrack may slow blood clotting. It is not wise to take bladderwrack together with other herbs or foods
which may also slow clotting. Slowing down the clotting will increase the chances of bruising and bleeding. The
medications and herbs may have similar effects on blood clotting include aspirin, clopidogrel (Plavix), diclofenac
(Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin
(Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), angelica, clove, danshen, fenugreek, feverfew, garlic,
ginger, ginkgo, Panax ginseng, poplar, red clover, turmeric, and others. Users should also avoid to take bladderwrack
together with iodine.
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PRODUCT DEVELOPMENT
Japanese researchers (Wenderoth, Lind & Ponack, L.L.P.) are developing apoptosis inducers, anticancer drugs
containing sulfated-fucose-containing polysaccharide(s) from Bladderwrack . [16]
 Another Japanese group (Birch
Stewart Kolasch & Birch) is developing a composition containing Bladderwrack to prevent skin aging, ameliorate
sensitive skin etc. They found that the Fucus vesiculosus extract might help hair restoring in a study of mice. [17]

Mc Laughlin and James Hugh developed an emollient skin conditioning cream using  Bladderwrack as the major
ingredient . [18] Chiarelli, Joseph A.; et al. applied Bladderwrack (Bladder Wrack)   in their facial moisturizer [19]
Mumoli, Jose Alejandro suggested to apply Bladderwrack as a phyto-therapeutic extract together with two
disintegrating agents as a single-dose quick dissolving cleansing agent. [20]

Larkins, Nicholas J. is developing a composition consisting of a Platelet Activating Factor (PAF) Inhibitor and (b) an
antioxidant. This composition may contain Fucus vesiculosus (Bladderwrack) [21] Daniels, Bruce Alan [Ali Kamarei,
Esq.] is developing a method and composition probably containing Bladderwrack (Bladder Wrack)   as the brown algae
to retard cardiovascular disorder. [22]  Daniels, Bruce Alan [Ali Kamarei, Esq.] is also developing a method and
composition probably containing Bladderwrack (Bladder Wrack)   as the brown algae to prevent or treat Type II
Diabetes Mellitus. [23]
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Bladderwrack is a rich source of mucilage, algin, mannitol, beta-carotene, zeaxanthin, iodine, bromine, potassium, volatile oils, and many other
minerals. In addition, bladderwrack may have health benefits on skin condition and other conditions.

Related Names: Fucus vesiculosus, Kelp
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[1] The American Heritage® Dictionary of the English Language, Fourth Edition]. [2] Newall C, Anderson, LA, Phillipson JD. Herbal
Medicines: A Guide for Health-Care Professionals. London, England: Pharmaceutical Press; 1996  [3]Newall C, Anderson, LA, Phillipson
JD. Herbal Medicines: A Guide for Health-Care Professionals. London, England: Pharmaceutical Press; 1996.] [4,5 ] Criado MT, Ferreiros
CM. Immunomodulatory effect produced in mice by a complex-carbohydrate specific lectin-like mucopolysaccharide from Fucus
vesiculosus. IRCS J Med Sci. 1983;11:286–287. Newall C, Anderson, LA, Phillipson JD. Herbal Medicines: A Guide for Health-Care
Professionals. London, England: Pharmaceutical Press; 1996.] [6] J Agric Food Chem. 2002 Feb 13;50(4):840-5].[7,8] Skibola CFBMC
Complement Altern Med. 2004 Aug 04;4(1):10.Skibola Brown kelp modulates endocrine hormones in female sprague-dawley rats and in
human luteinized granulosa cells. J Nutr. 2005 Feb;135(2):296-300] [9] Fujimura T el al Biol Pharm Bull. 2000 Oct;23(10):1180-4]. [10] J
Cosmet Sci. 2002 Jan-Feb; 53 (1): 1-9]. [11] Norman JA, Pickford CJ, Sanders TW, et al. Human intake of arsenic and iodine from
seaweed-based food supplements and health foods available in the UK. Food Addit Contam. 1987;5:103–109.] [12] Harrell BL, Rudolph
AH. Kelp diet: a cause of acneiform eruption [letter]. Arch Dermatol. 1976;112:560]. [13-15] Walkiw O, Douglas DE. Health food
supplements prepared from kelp—a source of elevated urinary arsenic [letter]. Can Med Assoc J. 1974;111:1301–1302, Walkiw O,
Douglas DE. Health food supplements prepared from kelp—a source of elevated urinary arsenic. Clin Toxicol. 1975;8:325–331, Conz
PA, La Greca G, Benedetti P, et al. Fucus vesiculosus: a nephrotoxic alga? Nephrol Dial Transplant. 1998;13:526-527] Breast Cancer
Prevention From The Sea, HealthDay, February 3, 2005 [16] Apoptosis inducers, Patent Application No. 20010034335 A1, October 25,
2001] [17] Cosmetics, Patent Application No. 20030039670, February 27, 2003] [18] Emollient skin conditioning cream and method,
patent application 20030133900 A1,July 17, 2003].[19] Example six, Personal care compositions containing inverse emulsion polymers,
patent application 20030147825, August 7, 2003] [20] Single-dose quick-dissolving cleansing agent with medicinal properties, patent
application 20030153482, August 14, 2003] [21] Example 1, Preparation for the relief of disease, patent application 20040022879,
February 5, 2004] [22] Seaweed extract composition for retardation of cardiovascular disorders and preservation of healthy cardiovascular
function, patent application 20040170645, September 2, 2004]. [23] Seaweed extract composition for treatment of diabetes and diabetic
complications, patent application 20040208893, October 21, 2004]. B1  Paradis ME,  et al, A randomised crossover placebo-controlled
trial investigating the effect of brown seaweed (Ascophyllum nodosum and Fucus vesiculosus) on postchallenge plasma glucose and
insulin levels in men and women. Appl Physiol Nutr Metab. 2011 Dec;36(6):913-9. B2 Min SK, et al, An Antithrombotic Fucoidan, Unlike
Heparin, Does Not Prolong Bleeding Time in a Murine Arterial Thrombosis Model: A Comparative Study of Undaria pinnatifida sporophylls
and Fucus vesiculosus. Phytother Res. 2011 Nov 14. [B3] Kwak KW et al, Biological effects of fucoidan isolated from Fucus vesiculosus
on thrombosis and vascular cells. Korean J Hematol. 2010 Mar;45(1):51-7. [B4] Hyun JH, et al, Apoptosis inducing activity of fucoidan in
HCT-15 colon carcinoma cells. Biol Pharm Bull. 2009 Oct;32(10):1760-4. [B5] Hirayasu H, et al, Sulfated polysaccharides derived from
dietary seaweeds increase the esterase activity of a lymphocyte tryptase, granzyme A. J Nutr Sci Vitaminol (Tokyo). 2005 Dec;51(6):475-7.
Bladderwrack Uses and Potential Health Benefits

Anti-aging
Bladderwrack extract containing fucoidan was found to promote fibroblast-populated collagen gel contraction by
increasing the integrin alpha2beta1 expression on fibroblast surface.. [9] A significant decrease in skin thickness and a
significant improvement in elasticity were found when a Bladderwrack gel (1%) topically onto human cheek skin twice
daily for five weeks. [10]

Anti-oxidative Activity
Bladderwrack has benefits of anti-oxidative activity. It was found boiled bladderwrack at low pHs had a strong
anti-oxidative activity, compared to other pHs. [6]

Atherosclerosis
Bladderwrack may benefit people at risks of atherosclerosis. [4,5]

Cancer
Three pre-menopausal women abnormal menstrual cycling patterns with were fed with bladderwrack. A significant
increase in menstrual cycle lengths and an anti-estrogenic and progestagenic effects were observed. Thus, seaweed
consumption may reduce the risk of estrogen-related cancers. [7, 8] Further, a study shows that bladderwrack fucoidan
may have potential in colon cancer treatment. [B4] Thus, bladderwrack may have benefits of anti-cancer activities.

Diabetes
Bladderwrack may benefit people at risk of diabetes. A study of 23 participants suggests a blend of Ascophyllum
nodosum and bladderwrack allows a reduction of insulin level but an increase in insulin sensitivity. [B1]

Heartburn
Bladderwrack may benefit people suffered from heartburn. [3] But, scientific evidence is insufficient to support this health
claim, more studies are needed.

Hypothyroidism
As a source of iodine, bladderwrack may benefit people at risk of hypothroidism. Actually, some people use
bladderwrack as supplement for hypothyroidism (under-active thyroid gland) [2]

IMMUNITY
Bladderwrack may strengthen immunity. [4, 5] Intake of sulfated polysaccharides, such as fucoidan or
lambda-carrageenan extracted from bladderwrack seaweeds, has been shown to enhance immune responses, resulting
in inhibition of tumor growth. [B5] Anyway, more studies are needed to support this benefit-claim.
Thrombosis
Fucoidan is a highly sulfated glycosaminoglycan from bladderwrack, which has a molecular structure similar to that of heparin. The antithrombotic
effects of fucoidan in vitro have been widely reported. Bladderwrack fucoidan has an inhibitory effect on proinflammatory cytokine production and
proliferation of vascular cells.[B3] In a study, thrombosis was induced on the carotid artery region of Balb/c mouse. Five minutes prior to thrombus
induction, mice were infused through the tail vein with either saline (control) or polysaccharides. Either bladderwrack fucoidan or heparin was
dosed at 0.1, 1.25, 2.5, 5.0, 10, 25, or 50 mg/kg intravenously. Both antithrombotic and bleeding effects were observed in a dose-dependent
manner for bladderwrack fucoidans and heparin. The total inhibition of thrombus formation was observed for unfractionated bladderwrack fucoidan
at 25 mg/kg where the time-to-stop bleeding was still significantly prolonged, by as much as 8 ± 1.7 min. Please, note that this study was done via
intravenous route while it is not sure if such benefit also appearance in oral dosage in humans. [B2]
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Bladderwrack weight loss and Bladderwrack cellulite
Marketers promote bladderwrack as an agent for weight loss and cellulite. When obesity is a direct result of thyroid disorders and low metabolism,
Bladderwrack may be of some help in weight control by boosting the thyroid's metabolism. They even claim there are some reports that
Bladderwrack can also reduce cellulite deposits in their websites. Though there are reports about how bladderwrack gel improve skin elasticity and
it is known that thyroid grand is related to metabolism, There is no direct scientific evidence on how bladderwrack extracts benefit cellulite and
weight loss directly (up to the date of August 21, 2011). Anyway, bladderwrack extracts may have benefits on of weight loss or on cellulite, but
studies are needed to support these health claims.
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DOSAGE OF BLADDERWRACK
There is insufficient information to determine the dosage of bladderwrack. But, the dosage is likely dependent on user's age, health, and several
other conditions. Keep in mind overdosage of bladderwrack can lead to hyperthyroidism, users may watch out if there are any signs of
hyperthyroidism, when they use the bladderwrack supplements. Do not to take bladderwrack in doses or dosages providing more than the
recommended daily intake of iodine.
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Different people may experience different side effects and benefits of a product. You are encouraged to report adverse
side effects of the bladderwrack supplements hat you took to FDA, its website is
www.fda.gov., or report the adverse
side effects to the manufacturer, you should be able to find the contact information on the label.

There are always new information. Please, send me an email (
zhion@zhion.com) to correct my mistake(s). Reasonable
care has been taken in preparing this document and the information provided herein is believed to be accurate. The
information is not intended to be a substitute for professional medical advice. It is important to seek the advice of a
physician about any medical condition or symptom or the benefits and side effects of a supplement or a drug product.
Finally, please, do not transfer the article to other website. Thank you.
If you like this article, you may like the following articles:

1. Side Effects and Health Benefits of Bladderwrack - Weight Loss and Cellulite (This Article)
2. Brown Seaweed (Wakame) Health Benefits and Side Effects
3. Uses and Health Benefits of Kelp
4. Chlorella Benefits and Dosage
5. Seaweed Health Benefits Reviews and Comments
6. Fucoxanthin  
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