The health benefits of
Tannic acid
According to Wikipedia, tannin is a polyphenol with a pKa about 10.
Tannic acid is present in oak, walnut and mahogany.  Traditionally, it has
been used as astringent, anti-bacterial and anti-enzymatic agents.
Recent in vitro/animal studies indicate it may have health benefits of
anti-cancer activities and on Alzheimer's disease and diabetes.

Liu X et al at Ohio University found that tannic acid induced
phosphorylation of the insulin receptor (IR) and Akt, as well as
translocation of glucose transporter 4 (GLUT 4), the protein factors
involved in the signaling pathway of insulin-mediated glucose transport.
They further demonstrated that tannic acid inhibited the expression of key
genes for adipogenesis. Thus, tannic acid may help to reduce blood
glucose levels without increasing adiposity (fat tissue). [1]

Ono K et al, at Kanazawa University, Japan, found tannic acid
dose-dependently inhibited fAbeta formation from beta-amyloid fibrils, as
well as their extension in vitro. Thus, tannic acid may benefit people at
risk of Alzheimer's disease. [2]

Tannic acid is a naturally occurring polyphenolic compound with
antioxidant and radical scavenging properties as well as
anticarcinogenic effects. Tannic acid inhibited proliferation of malignant
human cholangiocytes in vitro. [5] Kamei H and co-workers from
Aichi-Gakuin University Hospital, Japan, found a significant suppression
of tumor growth when tannic acid was cultured together with human
malignant tumors (HCT-15 and AGS). [3] Chen X and co-workers at
Science Applications International Corporation, Maryland, reported tannic
acid specifically inhibited CXCL12-induced human monocyte migration.
Studies showed interaction between the chemoattractant
CXCL12/stromal cell-derived factor-1alpha and its receptor CXCR4 plays
a pivotal role in the metastasis of various tumors. [4]

This article is for reference only. Please, consult with your doctor for
any question and before taking any supplement.
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Reference
[1] Liu X, et al, Tannic acid stimulates glucose transport and inhibits
adipocyte differentiation in 3T3-L1 cells. J Nutr. 2005 Feb;135(2):165-71.
[2] Ono K, et al, Anti-amyloidogenic activity of tannic acid and its activity to
destabilize Alzheimer's beta-amyloid fibrils in vitro. Biochim Biophys Acta.
2004 Nov 5;1690(3):193-202. [3] Kamei H, et la, Tumor cell growth
suppression by tannic acid. Cancer Biother Radiopharm. 1999
Apr;14(2):135-8. [4] Chen X, et al, Tannic acid is an inhibitor of CXCL12
(SDF-1alpha)/CXCR4 with antiangiogenic activity. Clin Cancer Res. 2003
Aug 1;9(8):3115-23. [5] Marienfeld C, et al, Inhibition of
cholangiocarcinoma growth by tannic acid. Hepatology. 2003
May;37(5):1097-104.
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