Resveratrol, one of the key ingredients in Yucca, is believed to contribute a part of the health benefits of
Yucca. [3] In this article, we are going to review the mechanism to cure arthritis and a few studies suggesting
that resveratrol may benefit those at risk of rheumatic arthritis and related diseases.

Researchers from University of Cincinnati explained the way to cure arthritis. Arthritis, an inflammation of the
joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour
necrosis factor and interleukin-1beta) and pro-inflammatory enzymes that mediate the production of
prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase), together with the expression
of adhesion molecules and matrix metalloproteinases, and hyperproliferation of synovial fibroblasts. All of
these factors are regulated by the activation of the transcription factor nuclear factor-kappaB. Thus, agents
that suppress the expression of tumor necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2,
lipooxygenase, matrix metalloproteinases or adhesion molecules, or suppress the activation of NF-kappaB,
all have potential for the treatment of arthritis. [6]

COX-1 and COX-2

Oxidative stress is related to a number of autoimmune diseases, including cancer and rheumatoid arthritis.
The main source of pathologic “reactive oxygen species” are the activated polymorphonuclear leukocytes.
Resveratrol was found to inhibit isolated polymorphonuclear leukocytes in a dose dependent manner. [2]
Researchers from Ludwig-Maximilians-University Munich demonstrated that resveratrol inhibited the
expression of VEGF, MMP-3, MMP-9 and COX-2 in human articularchondrocytes stimulated with the pro-
inflammatory cytokine IL-1beta. Furthermore, they demonstrated resveratrol suppressed apoptosis and
inflammatory signaling through its actions on the NF-kappaB pathway in human chondrocytes. [4]
Researchers from University of Graz, Australia, also showed that resveratrol possessed COX-1 inhibition,
COX-2 inhibitory potential and an LTB 4 formation inhibitory activity in an in vitro study. [3]

Anabolic Mediator

Researches from Rush University Medical Center found resveratrol is a potent anabolic mediator of bovine
intervertebral disc cartilage homeostasis from a vitro study, revealing its potential as a unique biologic
treatment to slow the progression of intervertebral disc degeneration. [1]

IL-1beta

The inflammatory process plays a pivotal role during the pathogenesis of osteoarthritis, dominated by
catabolic processes initiated by pro-inflammatory cytokines such as IL-1beta. Researchers from Ludwig-
Maximilians-University Munich found resveratrol reversed significantly IL-1beta-reduced cell proliferation and
blocked IL-1beta-stimulated cell membrane bound- and mature IL-1beta synthesis in chondrocytes.
Furthermore, resveratrol was able to inhibit the IL-1beta-induced degradation of mitochondria and apoptosis
in chondrocytes in a time-dependent manner. They also found that resveratrol was able to reverse the IL-
1beta-induced up-regulation of reactive oxygen species (ROS) in chondrocytes. [5]

Macrophage Migration Inhibitory Factor

Molnar V and Garai J. from University of Pécs, Hungary, considered the cytokine macrophage migration
inhibitory factor as a crucial factor in the pathogenesis of rheumatoid arthritis. They found resveratrol was a
potent inhibitor as the antipyretic-analgetic drug acetaminophen. [7]

Nuclear factor kappa B (NF-kappaB) / Animal Study

Nuclear factor kappa B (NF-kappaB), is a pivotal transcription factor involved inthe activation of the TNF-
alpha and IL-1beta genes. Activation of NF-kappaB insynovial cells is a feature seen in arthritis patients.
Resveratrol is potent and specific inhibitor of TNF-alpha and IL-1beta induced NF-kappaB activation.
Researchers from Inönü University Medical Faculty, Turkey, found intra-articular injections of resveratrol on
cartilage and synovium could significantly decreased cartilage destruction in an experimental rabbit
inflammatory arthritic model. [8]

Reference:

[a1] Li X, Phillips FM, An HS, Ellman M, Thonar EJ, Wu W, Park D, Im HJ. The action of resveratrol, a phytoestrogen
found in grapes, on the intervertebral disc. Spine. 2008 Nov 15;33(24):2586-95. [a2] Perecko T, Jancinova V,
Drabikova K, Nosal R, Harmatha J. Structure-efficiency relationship in derivatives of stilbene. Comparison of
resveratrol, pinosylvin and pterostilbene. Neuro Endocrinol Lett. 2008 Oct;29(5):802-5. [a3]: Wenzig EM, Oleszek W,
Stochmal A, Kunert O, Bauer R. Influence of phenolic constituents from Yucca schidigera bark on arachidonate
metabolism in vitro.J Agric Food Chem. 2008 Oct 8;56(19):8885-90. Epub 2008 Sep 9. [a4] Shakibaei M, Csaki C,
Nebrich S, Mobasheri A. Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in
human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem
Pharmacol. 2008 Dec 1;76(11):1426-39. Epub 2008 Jun 3. [a5] Csaki C, Keshishzadeh N, Fischer K, Shakibaei M.
Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem Pharmacol. 2008 Feb 1;
75(3):677-87. Epub 2007 Sep 18. [a6] Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal
A, Aggarwal BB. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol. 2007 Jun;7(3):344-51.
Epub 2007 May 1. [a7] Molnar V, Garai J. Plant-derived anti-inflammatory compounds affect MIF tautomerase activity.
Int Immunopharmacol. 2005 May;5(5):849-56. Epub 2005 Jan 27. [a8] Elmali N, Baysal O, Harma A, Esenkaya I,
Mizrak B. Effects of resveratrol in inflammatory arthritis. Inflammation. 2007 Apr;30(1-2):1-6.-----
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RESVERATROL arthritis
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