The health benefits of
Geraniol
August 2008
Geraniol, also called rhodinol, is a monoterpenoid and an
alcohol. It is the primary part of oil-of-rose and palmarosa oil.
It is also produced by the scent glands of honey bees to help
them mark nectar-bearing flowers and locate the entrances
to their hives.

Geraniol is commonly expressed as Geraniol 60, Geraniol
85, and Geraniol 95. Geraniol 60 refers to "40% of the oil is
Nerol"; Geraniol 85 refers to "15% of the oil is Nerol" and
Geraniol 95 refers to "5% of the oil is Nerol".  Nerol is a
monoterpene , which can be extracted from attar of roses, oil
of orange blossoms and oil of lavender. [1]

Geraniol is used in perfumes and some skin preparations
while researchers are studying its anti-tumor activities.

Dietary geraniol (0.65, 6.5 and 65 mmol/kg diet) was fed to
female C57BL mice for 14 d before and for 21 d after tumor
transplant. Tumor growth was suppressed (P < 0.02) by 6.5
and 65 mmol geraniol/kg diet. [2,4]

Burke YD at Indiana University-Purdue University found that
isoprenoids such as farnesol, geraniol, and perillyl alcohol
suppressed pancreatic tumor growth without significantly
affecting blood cholesterol levels. Significant (60-90%)
inhibition of the anchorage-independent growth of human
MIA PaCa2 pancreatic tumor cells was attained with 25
microM farnesol, 25 microM geranylgeraniol, 100 microM
perillyl amine, 100 microM geraniol, or 300 microM perillyl
alcohol. Syrian Golden hamsters (transplanted PC-1 hamster
pancreatic adenocarcinomas ) fed geraniol or farnesol at 20
g/kg diet exhibited complete inhibition of PC-1 pancreatic
tumor growth. [3]

Carnesecchi S and colleagues at Institut de Recherche
contre les Cancers de l'Appareil Digestif, France, found that
geraniol (400 microM) caused a 70% inhibition of growth of
human colon cancer cell line (Caco-2), with cells
accumulating in the S transition phase of the cell cycle, and
concomitant inhibition of DNA synthesis. No signs of
cytotoxicity or apoptosis were detected. Geraniol caused a
50% decrease of ornithine decarboxylase activity, a key
enzyme of polyamine biosynthesis, which is enhanced in
cancer growth. This led to a 40% reduction of the intracellular
pool of putrescine. Geraniol also activated the intracellular
catabolism of polyamines, indicated by enhanced polyamine
acetylation. [5]

This article can not be used as medical advice. Please, consult with your
medical doctor for any question or before taking any drug products and
supplements. ALL RIGHTS RESERVED zhion 2008

Reference
[1] US Patent Application 20080020078 [2] Yu SG et al, Geraniol, an inhibitor of
mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas
transplanted to rats and mice. J Nutr. 1995 Nov;125(11):2763-7. [3] Burke YD Inhibition
of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids.
1997 Feb;32(2):151-6. [4] Yu SG et al Geraniol, an inhibitor of mevalonate biosynthesis,
suppresses the growth of hepatomas and melanomas transplanted to rats and mice. J
Nutr. 1995 Nov;125(11):2763-7. [5] Carnesecchi S, et al, Geraniol, a component of plant
essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J
Pharmacol Exp Ther. 2001 Jul;298(1):197-200.