daidzein supplements, daidzein side effects, benefits
daizein and genistein, isoflavone and phytoestrogen, ZHION.COM  August 30 2011
Daidzein

7-hydroxy-3- (4-hydroxyphenyl)-4H -1-benzopyran-4-one, 4', 7-dihydroxyisoflavone Formula: C15H10O4;
Molecular weight: 254.24

Daidzein is an isoflavone as it has the typical C6-C3-C6 structure. It is also a phytoestrogen as it has some
estrogen activity. Other isoflavones include genistein and glycitein.

Daidzein is found in the stems of the fava bean (Vicia faba) and roots of kudzu vine (Pueraria lobata) and a
remarkable amount of genistein is stored in the leaves of Psoralea corylifolia (Indian bread root). While,
legumes, lupine (Lupinus spp.), fava bean, (Vicia faba), soybeans (Glycine max), kudzu (Pueraria lobata),
psoralea (Psoralea corylifolia), and miso (a fermented soybean product) are excellent food sources for both
genistein and daidzein. [5]

Daidzein benefits - immunity
Zhang R, et al at Tsinghua University, China, reported that daidzein could exert a stimulatory effect on
nonspecific immunity by increasing the phagocytic response of peritoneal macrophages and thymus weight in
an animal study. They also observed enhanced cell-mediated immunity as increase in lymphocyte proportion
of peripheral blood. [7]

Daidzein benefits - cancer prevention
The anti-estrogenic effect of daidzein may explain its anti-carcinogenic and anti-osteoporotic activities.

In cell cultures, daidzein exerts its anticancer effects in human breast cancer cells via cell cycle arrest at the
G1 and G2/M phases, Choi EJ and Kim GH from Duksung Women's University, South Korea, observed
1-100muM daidzein significantly inhibited MCF-7 and MDA-MB-453 cell proliferation in a dose- and
time-dependent manner and resulted in significant cell cycle arrest in the G1 and G2/M phases after 72h of
treatment. In addition, daidzein caused the accumulation of MDA-MB-453 cells in sub-G0 phase and in a
dose-dependent manner. Daidzein also increased caspase-9 activity in both cells - a biomarker of apoptosis
induction.

Daidzein benefits - Bone
In 1998, King RA and Bursill DB at University of Adelaide, South Australia concluded that the bioavailabilities
of daidzein and genistein soybean flour-based meals are similar in six human subjects. [3]

Daidzein seems to be able to reduce the risk for osteoporosis. Studies have shown that daidzein stimulates
the formation of osteoblasts, which are cells that produce bone mass.

Japanese researchers, at Hoechst Japan Limited, found that daidzein stimulated bone resorption in the pit
formation assay at the concentration of 10(-8)-10(-10) M. On the other hand, genistein and ipriflavone at
these concentrations did not have any effect on pit formation. They speculated that daidzein had the ability to
induce osteoclasts directly or indirectly from their progenitors. [6]

In 2000, Picherit C and his co-workers at Laboratoire des Maladies Métaboliques et Micronutriments, France,
found that consumption of 17 alpha-ethinylestradiol or daidzein was more efficient than genistein in
preventing ovariectomy-induced bone loss in rats. [2] Menon LG and co-workers at Amala Cancer Research
Center, India, found genistein, but not daidzein, had a significant effect on the reduction of lung metastasis
induced by B16F-10 melanoma cells. Genistein treatment also increased the life span of the tumor-bearing
animals. [4]

Reference
[1] Choi EJ, Kim GH. Daidzein causes cell cycle arrest at the G1 and G2/M phases in human breast cancer MCF-7 and
MDA-MB-453 cells. Phytomedicine. 2008 Jun 9. [2] Picherit C, et al Daidzein is more efficient than genistein in preventing
ovariectomy-induced bone loss in rats. J Nutr. 2000 Jul;130(7):1675-81. [3] King RA and Bursill DB, Plasma and urinary
kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr. 1998 May;67(5):867-72.
[4] Menon LG, et al, Effect of isoflavones genistein and daidzein in the inhibition of lung metastasis in mice induced by B16F-10
melanoma cells. Nutr Cancer. 1998;30(1):74-7. [5] Kaufman PB, et al, A comparative survey of leguminous plants as sources
of the isoflavones, genistein and daidzein: implications for human nutrition and health. J Altern Complement Med. 1997
Spring;3(1):7-12. [6] Tobe H, et al, Daidzein stimulation of bone resorption in pit formation assay. Biosci Biotechnol Biochem.
1997 Feb;61(2):370-1. [7] Enhancement of immune function in mice fed high doses of soy daidzein. Nutr Cancer.
1997;29(1):24-8.
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