The health benefits
of
capsaicin

Pain Killer

Drs Knotkova H, Pappagallo M, Szallasi A. Israel Medical Center
Medicine, New York, wrote:

The capsaicin receptor TRPV1 is a polymodal nociceptor exhibiting a dynamic
threshold of activation that could be lowered under inflammatory conditions.
Consistent with this model, TRPV1 knock-out mice are devoid of
post-inflammatory thermal hyperalgesia. TRPV1 desensitization of primary
sensory neurons is a powerful approach to relieve symptoms of nociceptive
behavior in animal models of chronic pain. However, over-the-counter capsaicin
creams have shown moderate to poor analgesic efficacy. This is in part related
to low dose, poor skin absorption, and compliance factors. Recently developed
site-specific capsaicin therapy with high-dose patches and injectable
preparations seem to be safe and reportedly provide long-lasting analgesia with
rapid onset. They argued that TRPV1 agonists and antagonists are not mutually
exclusive but rather complimentary pharmacologic approaches for pain relief. [1]

Ulcer

Satyanarayana MN. CFTRI, Mysore, India. mnnanu@lycos.com wrote:

In recent years, infection of the stomach with the organism Helicobacter Pylori
has been found to be the main cause of gastric ulcers. Excessive acid secretion
in the stomach, reduction in gastric mucosal blood flow, constant intake of
non-steroid anti-inflammatory drugs (NSAIDS), ethanol, smoking, stress are also
considered responsible for ulcer formation. The prevalent notion among sections
of population in India and perhaps in others is that "red pepper" popularly known
as "Chilli," a common spice consumed in excessive amounts leads to "gastric
ulcers" in view of its irritant and likely acid secreting nature. Persons with ulcers
are advised either to limit or avoid its use. However, investigations carried out in
recent years have revealed that chilli or its active principle "capsaicin" is not the
cause for ulcer formation but a "benefactor." Capsaicin does not stimulate but
inhibits acid secretion, stimulates alkali, mucus secretions and particularly gastric
mucosal blood flow which help in prevention and healing of ulcers. Capsaicin
acts by stimulating afferent neurons in the stomach and signals for protection
against injury causing agents. [2]

Dairam A, Fogel R, Daya S, Limson JL.Rhodes University,South Africa,
wrote:

Research demonstrates that antioxidants and metal chelators such as curcumin,
capsaicin, and S-allylcysteine may be of beneficial use in the treatment of
neurodegenerative diseases, such as Alzheimer's disease. [3]


This article is for reference only. If you have any question, please, consult with your
doctor. Please note that the performance of a supplement or extract in animal studies
may be different in human body. ALL RIGHTS RESERVED DO NOT COPY NOR TRANSFER
THE CONTENT TO OTHER SITES. ZHION 2008

Reference
[1] Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival? Clin J
Pain. 2008 Feb;24(2):142-54. [2] Capsaicin and gastric ulcers.Crit Rev Food Sci Nutr.
2006;46(4):275-328. [3] Antioxidant and iron-binding properties of curcumin, capsaicin,
and S-allylcysteine reduce oxidative stress in rat brain homogenate. J Agric Food Chem.
2008 May 14;56(9):3350-6. Epub 2008 Apr 19. 2008

This page was maintained on
March 8, 2009
ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD CONSULT WITH YOUR
DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2008. DO NOT COPY NOR TRANSFER ARTICLES TO OTHER WEBSITES NOR OTHER
FORMS OF PUBLICATIONS.
ARTICLE INDEX