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A liposome is a closed vesicle having a lipid bimolecular membrane formed mainly of a
phospholipid. Since a liposome has a similar structure and a similar function as a cell
membrane, It will not stimulate easily an immunity system (low antigen) and it has a high safety
level as a material.
LIposome can retain a water-soluble drug in an internal aqueous phase which is surrounded by
a lipid bimolecular membrane, and it can retain a fat-soluble drug inside the lipid bimolecular
membrane. Therefore, it is possible to stably encapsulate medicinal properties which are
originally easily deactivated.
Active research and development have been made for application of a liposome in the field of
pharmaceutical products, foods and cosmetics. In particular, it has been widely studied a
medicine encapsulated liposome which is effectively applicable to a drug delivery system and
a preparation method of a medicine encapsulated liposome.
Example of Application
The therapeutic benefit of many drugs is limited by low uptake of the compound by the target
cells. Generally, for maximum therapeutic benefit, delivery of the compound to the cytoplasmic
or nuclear compartment of the cell is desired, where gene transcription, and translation of
mRNA into protein take place. Lipophilic compounds, including many small, uncharged
compounds, can permeate across the cell membrane and allow relatively efficient uptake by
the cell. However, for a variety of larger and/or charged molecules. Liposomes have been
commonly applied to improve the absorption of larger or charged molecules to the cells.
SOURCE US PATENT APPLICATION NOs. 20100209494 20100215582