Gotu kola Herb Reviews
Recent studies demonstrated that Gotu kola herb destroyed cultured tumor cells in the laboratory setting (in vitro),
promoted wound healing and more. This article summarize a few possible gotu kola benefits. Gotu Kola (Centella
asiatica) is a slender, creeping plant that grows mainly in swampy areas of India, Sri Lanka, Madagascara and South
Africa. Because gotu kola's leaves are about the size of an old British penny, people also called it  Indian pennywort,
marsh penny or water pennywort.

Gotu Kola herb was considered as a spiritual herb in Ayurveda and it is used with meditation to revitalize the nerves
and brain cells. In traditional medicine, gotu kola is believed to help develop the crown charka, the energy center at
the top of the head. Gotu Kola is commonly used for "brain elevation". As early as in 1950s, Ratsimamanga AR et al
and Antonelli NS et al reported that gotu kola herb might have benefits on refractory wounds, such as leprosy, lupus
and ulcers.[1-5].  And the key ingredient of gotu kola herb is known to be asiatic acid, a pentacyclic triterpene. [6-9]
Gotu Kola Tea has been claimed to have benefits of enhancing brain and memory functions, treating Alzheimer's
Disease and overcoming stress and fatigue by online venders. Unfortunately, these claims have no or very limited
direct scientific support. Clinical studies or at least more animal studies are needed to verify these gotu kola tea
benefits. Some websites states that asiaticoside is associated with tumor in an animal study. But an in vitro study
indicates asiaticoside is an anti-tumor agent and enhanced anti-tumor activity of vincristine. [A5] However,
overdosage of gotu kola may cause side effects such as headache, stomach upset, nausea, dizziness, and extreme
drowsiness.
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Gotu Kola, Benefits, Side Effects, Cellulite, Hair Loss, Tea
Gotu kola tea
gotu kola herb reviews, updated on October 23, 2011
A1 Krishnamurthy RG, Senut MC, Zemke D, Min J, Frenkel MB, Greenberg EJ, Yu SW, Ahn N, Goudreau J, Kassab M, Panickar KS, Majid A. Asiatic acid, a
pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia. J Neurosci Res. 2009 Aug 15;87(11):2541-50.
A2. Joy J, Nair CK. Protection of DNA and membranes from gamma-radiation induced damages by Centella asiatica. J Pharm Pharmacol. 2009
Jul;61(7):941-7.  A3 Hartog A, Smit HF, van der Kraan PM, Hoijer MA, Garssen J.  In vitro and in vivo modulation of cartilage degradation by a standardized
Centella asiatica fraction.Exp Biol Med (Maywood).  2009 Jun;234(6):617-23. Epub 2009 Mar 23.  [A4] Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B,
Porter JW, Young KA, Manyam BV. Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model.
Phytother Res. 2009 Jan;23(1):14-9.  [A5] Huang YH, Zhang SH, Zhen RX, Xu XD, Zhen YS. Asiaticoside inducing apoptosis of tumor cells and enhancing
anti-tumor activity of vincristine. Ai Zheng. 2004 Dec;23(12):1599-604.1. RATSIMAMANGA AR et al., Therapie. 1956;11(1):125-49. 2. RATSIMAMANGA AR et
al., Lyon Med. 1957 Apr 28;89(17):389-95. 3. RATSIMAMANGA AR et al., Presse Med. 1958 Dec 6;66(86):1933 passim. 4. Fubcato M., Minerva Chir. 1960
Nov 30;15:1235-8. 5. Antonellic NS, Prensa Med Argent. 1961 Nov 24;48:3154-6. 6. RAHANDRAHA T et al, Ann Pharm Fr. 1963 Apr;21:313-20. 7.
RAHANDRAHA T et al, Ann Pharm Fr. 1963 Jul-Aug;21:561-7. 8. Boiteau P et al, C R Acad Sci Hebd Seances Acad Sci D. 1967 Jan 9;264(2):407-10. 9. Park
BC et al, Cancer Lett. 2005 Jan 31;218(1):81-90 10 [Jayashree G et alFitoterapia. 2003 Jul;74(5):431-4]. [11] Angiology. 1987 Jan;38(1 Pt 1):46-50]. [12]
Incandela L et al Angiology. 2001 Oct;52 Suppl 2:S9-13, Angiology. 2001 Oct;52 Suppl 2:S61-7, Angiology. 2001 Oct;52 Suppl 2:S55-9, Angiology. 2001
Oct;52 Suppl 2:S49-54][13] Tenni R et al Ital J Biochem. 1988 Mar-Apr;37(2):69-77].[14] Shukla et al Phytother Res. 1999 Feb;13(1):50-4][15] Lu L et alInt J
Dermatol. 2004 Nov;43(11):801-7].[16] J Tradit Chin Med. 1989 Jun;9(2):113-6][17] Guo JS et al,Planta Med. 2004 Dec;70(12):1150-4]. [18] Indian J Exp Biol.
2001 Feb;39(2):137-42].19] Life Sci. 2004 Mar 19;74(18):2237-49][17] Huang YH et al Ai Zheng. 2004 Dec;23(12):1599-604][18] Park BC et alCancer Lett.
2005 Jan 31;218(1):81-90]. [19] Yoshida M et al Biol Pharm Bull. 2005 Jan;28(1):173-5][20] Biol Pharm Bull. 2005 Jan;28(1):173-5][21] Life Sci. 2004 Dec
17;76(5):585-97][22] Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Aug;24(8):731-4].
This website discusses the benefits and side effects of various supplements, herbs and drug products. Different side
effects to FDA, its website is
www.fda.gov., or report the adverse side effects to the manufacturer, you should be able
to find the contact information on the label.

There are always new information. Please, send me an email (
zhion@zhion.com) to correct my mistake(s). Reasonable
care has been taken in preparing this document and the information provided herein is believed to be accurate. The
information is not intended to be a substitute for professional medical advice. It is important to seek the advice of a
physician about any medical condition or symptom or the benefits and side effects of a supplement or a drug product.
Finally, please, do not transfer the article to other website. Thank you. ALL RIGHTS RESERVED.
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Gotu Kola Tea
Gotu kola is available in teas and as dried herbs, tinctures, capsules, tablets, and ointments. A scientific study
about how the fermentation affecting the antioxidant capacity of gotu kola tea has been reported. Here is a
summary of the research findings:

Gotu kola was exposed to various fermentations: no fermentation (0 min), partial fermentation (120 min) and full
fermentation (24 h). Total phenolic content and ferric-reducing antioxidant power of gotu kola tea were studied as a
function of water temperature (60, 80 or 100 °C), the brewing stage (one, two or three) and the brewing time (1, 3,
5, 10, 15 or 20 min). The optimum brewing procedure was adopted to study the antioxidant properties and phenolic
compounds in gotu kola tea.

The optimum extraction efficiency of gotu kola tea was achieved at 100 °C after a 10 min brewing time, and
decreased substantially after applying multiple brewing steeps. However, no significant different was found between
the second and third infusions. The non-fermented gotu kola tea had the highest antioxidant activity.
Gallic acid,
naringin, chlorogenic acid, catechin, rutin, rosmarinic acid and quercetin were identified to present. Luteolin and
kaempferol were only found in 80% methanol extraction method.The authors concluded that gotu kola herbal teas
should be prepared at 100 °C for 10 min to obtain the optimum antioxidant capacity. They also encouraged multiple
brewing steps in gotu kola tea preparation.
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Gotu Kola Benefits and Side Effects
For detailed information about gotu kola benefits and side effects, please, click: gotu kola benefits or gotu kola side
effects.

Reference
Ariffin F, et al, Antioxidant capacity and phenolic composition of fermented Centella asiatica herbal teas. J Sci Food
Agric. 2011 Oct 10.