Crataegus pinnatifida benefits
Crataegus pinnatifida, Chinese hawthorn, Chinese hawberry, shānzhā, 山楂, 山查, 山楂果, 山查果, mountain hawthorn,
mountain hawberry, Shan Zha, shanzha
Crataegus pinnatifida is a small to a medium-sized tree as well as the fruit of the tree. The fruit is bright red, 1.5 inches
in diameter. In Chinese cuisine, Crataegus pinnatifida fruits are used in dessert, jam, jelly, wine, candied fruit and haw
flakes. [Wikipedia, June 2013]
The leaf of Crataegus pinnatifida is popularly consumed either raw or cooked to improve digestion and promote blood
circulation in China.  Crataegus pinnatifida also has a long history of use in traditional oriental herbal medicine to
stimulating digestion and improving blood circulation. 
Composition - Polyphenols
Chinese hawthorn (Crataegus pinnatifida Bge.) fruits are rich in polyphenols. Examples of these polyphenols include
epicatechin, procyanidin B2, procyanidin B5, procyanidin C1, hyperoside, isoquercitrin and chlorogenic acid. The
polyphenols constitute the potential health benefits of the Crataegus pinnatifida. 
Potential Health Benefits
In a study of mouse, oral administration of an extract of Crataegus pinnatifida at a dosage of 50 mg/kg weight
promoted hair growth by inducing anagen phase in mice in telogen, reflected by color of skin, thickness of hair shaft,
and density of hair. The number and the size of hair follicles were also increased. 
Recent trials have demonstrated the efficacy of Crataegus pinnatifida fruit in lowering blood cholesterol and the risk of
cardiovascular diseases. 
Eye drops made of Crataegus pinnatifida (i.e. Shanzha) and 0.1% hydroxypropyl methyl cellulose solution had a
positive effect on selenite-induced cataract. 
Inflammation / Asthma
In a study of mice, Crataegus pinnatifida ethanolic extracts protect against allergic airway inflammation and can act as
an MMP-9 modulator to induce a reduction in ICAM-1 and VCAM-1 expression. 
The fruit of Crataegus pinnatifida has also demonstrated anti-inflammatory and anti-tumour activities in studies. 
The antithrombotic activity of the isolated compounds from Crataegus pinnatifida was investigated on the transgenic
zebra fish system. Among them, eriodectyol (6) potently inhibited the production of thrombus. 
Lipid Levels (Triglycerides and Cholesterol)
In a study of 30 subjects with high lipid levels, treatment of Shanzha xiaozhi capsule led to a reduced levels of
triglyceride and choleserol. The author thinks that there may be protection against atherosclerosis. 
In a study of hamsters suffered from dyslipidemia and obesity, treatment of shanzha for 7 days led to reduced body
weights, and certain adipose tissues. Treatment of shanzha also reduced the plasma levels of triglyceride, total
cholesterol and LDL-cholesterol. 
A formula of Traditional Chinese Medicine consisting of Astragalus membranaceus, Morus alba, Crataegus pinnatifida,
Alisma orientale, Salvia miltiorrhiza, and Pueraria lobata reversed fatty liver and liver damage and caused significant
reduction in alcohol-induced lipid hepatic accumulation in a study of rats. 
Crataegus pinnatifida (i.e. Shanzha) is possibly safe for most healthy adults at regular doses for a short period of time.
However, overdose or prolonged use of Shanzha may lead side effects such as nausea, stomach upset, fatigue,
sweating, headache, agitation, insomnia, nose-bleeding, palpitations and some other issues for some users.
Shanzha may also interact with certain drugs, e.g. digoxin (Lanoxin). You must consult with a medical doctor before
taking Shanzha, if you are on medication or if you have health issues.
 Wang T. et al, J Agric Food Chem. 2011 May 11;59(9):4987-94
 Shin HS et al, Phytother Res. 2012 Nov 12
 Jurikova T et al, Molecules. 2012 Dec 6;17(12):14490-509
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 Shin IS, et al, PLoS One. 2012;7(9):e45734.
 Zhao HY, Wang WH., Zhong Yao Cai. 2006 Jun;29(6):629-31.
 Kuo DH et al, J Ethnopharmacol. 2009 Jul 30;124(3):544-50.
 Wang T. et al, Biol Trace Elem Res. 2011 Jul;142(1):106-16.
 Kwon HJ, et al, World J Gastroenterol. 2005 Sep 21;11(35):5512-6.
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PHYTONUTRIENTS AND DRUG PRODUCTS. THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND DISEASES.
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