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Amla supplement, extract, benefits, medical uses - ZHION.COM
- June 18, 2011
Amla (syn. Emblica officinalis), also known as Indian gooseberry, is a deciduous tree of the
Phyllanthaceae family. The taste of Indian gooseberry is sour, bitter and astringent, and is quite
fibrous. In India, it is common to eat gooseberries steeped in salt water and turmeric. The fruit is
used either alone or in combination with other plants to treat many ailments such as common
cold and fever; as a diuretic, laxative, liver tonic, refrigerant, stomachic, restorative, alterative,
antipyretic, anti-inflammatory, hair tonic; to prevent peptic ulcer and dyspepsia, and as a
digestive. [Eur. J Cancer Prev. 2011 May;20(3):225-39]

In Ayurvedic, Amla is a component for a herbal formula - Chyawanprash, while in Chinese
traditional therapy, this fruit (yuganzi;
余甘子) is used to cure throat inflammation. [Wikipedia,
2011]

Research Studies
Preclinical studies have shown that amla possesses antipyretic, analgesic, antitussive,
antiatherogenic, adaptogenic, cardioprotective, gastroprotective, antianemia,
antihypercholesterolemia, wound healing, antidiarrheal, antiatherosclerotic, hepatoprotective,
nephroprotective, and neuroprotective properties. Amla is also reported to possess
radiomodulatory, chemomodulatory, chemopreventive effects, free radical scavenging,
antioxidant, anti-inflammatory, antimutagenic and immunomodulatory activities, properties that
are efficacious in the treatment and prevention of cancer. [Eur J Cancer Prev. 2011 May;20(3):
225-39.] Unfortunately, most are test-tube or animal studies, clinical studies are needed to
prove most of the claims. Anyway, we'll review some recent interesting research findings:

Its Components
Its components include gallic acid, ellagic acid, pyrogallol, some norsesquiterpenoids, corilagin,
geraniin, elaeocarpusin, and prodelphinidins B1 and B2.

Amla may benefit people at risk of cancers
Amla was found to have the potential to suppress carcinogen-induced response in rat skin,
intestine and liver etc.

The chemopreventive potential of Emblica officinalis fruit extract on 7, 12-dimethyabenz(a)
anthrecene induced skin tumorigenesis was demonstrated in Swiss albino mice. [Sancheti G,
Asian Pac J Cancer Prev. 2005 Apr-Jun;6(2):197-201]

Irradiation of animals resulted in a dose-dependent elevation in lipid peroxidation and a
reduction in glutathione as well as catalase concentration in the intestine at 1 hour post-
irradiation. In contrast, Amla extract treatment before irradiation caused a significant depletion
in lipid peroxidation and elevation in glutathione and catalase levels. [Jindal A et al Integr
Cancer Ther. 2009 Mar;8(1):98-105.]

Pretreatment with defatted methanolic amla fruit extract showed significant partial recovery of
pathological manifestations and suppressed the tumor forming potential of 2-
acetylaminoflourine. [Sultana SJ et al, Ethnopharmacol. 2008 Jun 19;118(1):1-6.]

Amla may benefit people at risk of high cholesterol
A significant decrease in fasting and 2-h post-prandial blood glucose levels on the 21st day in
both normal and diabetic subjects receiving 1, 2 or 3 g Amla powder per day. Significant
decreases were also observed in total cholesterol and triglycerides in both normal and diabetic
volunteers on day 21 that were given either 2 or 3 g Amla powder per day. However, diabetic
volunteers receiving only 3 g Amla powder exhibited a significant decrease in total lipids on day
21. Both normal and diabetic volunteers receiving 2 or 3 g Amla powder significantly improved
high-density lipoprotein-cholesterol and lowered low-density lipoprotein-cholesterol levels.  [Int J
Akhtar MS, Food Sci Nutr. 2011 Apr 18]

Amla may benefit people at risk of diabetes
Results showed that methanol extract of Amla can act as potent α-amylase and α-glucosidase
inhibitor. The extract significantly inhibited the oxidation of LDL under in vitro conditions.
Analysis revealed that Amla methanol extract contains ellagic acid and ascorbic acid as the
major compound. [Food Chem Toxicol. 2011 Jan;49(1):125-31]

Oral administration of a 1:1 mixture of
EGCG (a green tea component) and Amla extracts for 3
months significantly improved antioxidant defense as well as diabetic and atherogenic indices
in uremic patients with
diabetes. [Chen TS, J Med Food. 2011 Jun 1]

Amla may benefit people at risk of epilepsy and seizures
The effect of seven days pretreatment of 300, 500 and 700 mg/kg doses of hydroalcoholic
extract of Amla administered intraperitoneally to rats was evaluated on pentylenetetrazole
induced seizures, cognitive deficit and oxidative stress markers viz malondialdehyde and
glutathione. The 500 and 700 mg/kg ip doses of Amla extract completely abolished the
generalized tonic seizures and also improved the retention latency in passive avoidance task.
[Indian J Exp Biol. 2010 May;48(5):474-8.]

Amla may benefit people at risk of pancreatitis
Amla treatment was found to be beneficial for treating acute pancreatitis in rats. Nucleic acid
content, rate of DNA synthesis, pancreatic proteins, and pancreatic amylase content were
significantly improved with the treatment. [J Med Food. 2011 Jan-Feb;14(1-2):147-55.]

Safety, Side Effects and Toxicity
No significant changes in hepatic function, renal function, or inflammatory responses were
observed after 3 months intake of a mixture of EGCG and Amla extract, in 13 uremic diabetic
patients. Uremic patients with diabetes suffer from high levels of oxidative stress due to regular
hemodialysis therapy (neutrophil activation induced by hemo-incompatibility between the
hemodialyser and blood) and complications associated with diabetes. [Chen TS, J Med Food.
2011 Jun 1.]

No report suggests amla may benefit people at risk of Alzheimer's Disease
As of June 19, 2011, I have not seen human studies regarding the use of amla supplement or
powder for
Alzheimer's Disease.

Skin
Amla fruit stimulated, the otherwise UVB inhibited cellular proliferation and protected pro-
collagen 1 against UVB-induced depletion via inhibition of UVB-induced matrix
metalloproteinase 1 in skin fibroblasts. Amla fruit exhibited inhibitory activity of hyaluronidase.
Treatment with Amla fruit also prevented UVB disturbed cell cycle to normal phase. [Adil MD et
al, J Ethnopharmacol. 2010 Oct 28;132(1):109-14]

NOTE
Discuss with your medical doctor before taking this supplement. This article is for your
information only. Do not copy or transfer the content to other websites or blogs. All rights
reserved 2011 ZHION.COM.