|What are the flaxseed oil side effects?
Up to the date this article is prepared, serious flaxseed oil side effects have not been reported. High dose flaxseed oil
side effects include non-formed feces, depression, anorexia, mild colic, high serum glucose and bilirubin levels.
[based on animal studies; 21]
Studies have found that eating fish (which contains EPA and DHA) regularly may reduce the risk of macular
degeneration, but a recent study found that diets rich in ALA may substantially increase the risk of this eye disease.
More research is needed. Until then, people with macular degeneration should get omega-3 fatty acids from sources
of EPA and DHA (such as fish or fish oil), rather than ALA. 
Although studies have found that eating fish (which contains the omega-3 fatty acids EPA and DHA) regularly may
reduce the risk of macular degeneration, a recent study including 2 large groups of men and women found that diets
rich in ALA may substantially increase the risk of this eye disease. More research is needed. Until then, people with
macular degeneration should get omega-3 fatty acids from sources of EPA and DHA (such as fish or fish oil), rather
Heated Flaxseed oil is not safe and it has serious side effects. The heated flaxseed oil side effects include liver
enlargement or even liver damage. Further, the fume from heated flaxseed oil may cause cancer.  During
gestation and lactation, female rats fed with heated flaxseed oil. Newborn rats found dead and their livers were
heavier and higher in lipid content.  .
 Haag M. Essential fatty acids and the brain. Can J Psychiatry. 2003 Apr;48(3):195-203  Yang L et al alpha-Linolenic acid but not
conjugated linolenic acid is hypocholesterolaemic in hamsters. : Br J Nutr. 2005 Apr;93 (4):433-8.  Mozaffarian D. Does alpha-linolenic
acid intake reduce the risk of coronary heart disease? A review of the evidence. Altern Ther Health Med. 2005 May-Jun;11 (3):24-30; quiz
31, 79.  Ramaprasad TR et al, Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids
in rats. Lipids. 2004 Jul;39(7):627-32.  Ristic-Medic D et al, Alpha-linolenic acid* and cardiovascular diseases. Med Pregl. 2003;56
Suppl 1:19-25. *flaxseed oil.  Ander BP et al, Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion
in normal and hypercholesterolemic Rabbits. J Nutr. 2004 Dec;134(12):3250-6.  Hansen RA et al, Effects of dietary flaxseed oil
supplementation on equine plasma fatty acid concentrations and whole blood platelet aggregation. J Vet Intern Med. 2002
Jul-Aug;16(4):457-63.  Cohen SL et al, Flaxseed oil and inflammation-associated bone abnormalities in interleukin-10 knockout mice.
J Nutr Biochem. 2005 Jun;16 (6):368-74.  Sankaran D. Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids
depends on the level and type of fat. Lipids. 2004 Mar;39(3):207-14.  Chen J et al Flaxseed and its components reduce metastasis
after surgical excision of solid human breast tumor in mice. Cancer Lett. 2005 May 2 Rao GN, Effect of melatonin and linolenic acid
on mammary cancer in transgenic mice with c-neu breast cancer oncogene. Breast Cancer Res Treat. 2000 Dec;64(3):287-96. 
Thompson LU et al, The effect of flaxseed oil may be related to its high alpha-linolenic acid. Carcinogenesis. 1996 Jun;17(6):1373-6. 
Haggans CJ The effect of flaxseed and wheat bran consumption on urinary estrogen metabolites in premenopausal women. Cancer
Epidemiol Biomarkers Prev. 2000 Jul;9(7):719-25.  Dwivedi C et al, Chemopreventive effects of dietary flaxseed oil on colon tumor
development. Nutr Cancer. 2005;51(1):52-8.  Alekseeva RI et al, Effects of a diet including linseed oil on clinical and metabolic
parameters in patients with type 2 diabetes mellitus. Vopr Pitan. 2000;69(6):32-5.  Jelinska M., Effects of dietary linseed, evening
primrose or fish oils on fatty acid and prostaglandin E2 contents in the rat livers and 7,12-dimethylbenz[a]anthracene-induced tumours.
Biochim Biophys Acta. 2003 Apr 17;1637(3):193-9.  Thuy NT et al, Comparative effect of dietary olive, safflower, and linseed oils* on
spontaneous liver tumorigenesis in C3H/He mice. J Nutr Sci Vitaminol (Tokyo). 2001 Oct;47(5):363-6. *flaxseed oil  Ogborn MR et al,
Dietary flax oil reduces renal injury, oxidized LDL content, and tissue n-6/n-3 FA ratio in experimental polycystic kidney disease. Lipids.
2002 Nov;37(11):1059-65.  Takemura N et al, Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in
hairless mice when compared with linoleic acids. Photochem Photobiol. 2002 Dec;76(6):657-63.  Metayer C. et al Cooking oil fumes
and risk of lung cancer in women in rural Gansu, China. Lung Cancer. 2002 Feb;35(2):111-7. Schumacher J et al, Clinical and
clinicopathologic effects of large doses of raw linseed oil* as compared to mineral oil in healthy horses. J Vet Intern Med. 1997
Sep-Oct;11(5):296-9.*flaxseed oil  Potteau B. Influence of heated linseed oil* on reproduction in the female rat and on the
composition of hepatic lipids in young rats Ann Nutr Aliment. 1976;30(1):67-88.*flaxseed oilF  Dunbar BL, Bigley KE, Bauer JE. Early
and sustained enrichment of serum n-3 long chain polyunsaturated fatty acids in dogs fed a flaxseed supplemented diet. Early and
sustained enrichment of serum n-3 long chain polyunsaturated fatty acids in dogs fed a flaxseed supplemented diet.  Mueller RS, et
al, Plasma and skin concentrations of polyunsaturated fatty acids before and after supplementation with n-3 fatty acids in dogs with
atopic dermatitis. Am J Vet Res. 2005 May;66(5):868-73.  Pinheiro MN Jr, et al, Oral flaxseed oil (Linum usitatissimum) in the
treatment for dry-eye Sjögren's syndrome patients Arq Bras Oftalmol. 2007 Jul-Aug;70(4):649-55.  Nordström DC, et al,
Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs.
safflower seed. Rheumatol Int. 1995;14(6):231-4.  Kaithwas G, et al, Therapeutic effect of Linum usitatissimum (flaxseed/linseed)
fixed oil on acute and chronic arthritic models in albino rats. Inflammopharmacology. 2010 Jun;18(3):127-36.  University of Maryland
online publication. 2011.
|Flaxseed oil benefits, flaxseed oil side effects
December 02, 2011
lignans in flaxseed
health benefits of