Contrave
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Contrave, an experimental weight-loss drug developed by
Orexigen Therapeutics Inc., has been shown to significantly
aid weight loss in three late-stage clinical trials. In one of the
trials, 48% of the patients lost more than 5% of their body
weight after 56 weeks, compared with 16.4% of those taking
a placebo. In another trial, the numbers were 56.3%
compared with 17.1% for controls.

The amount of weight loss, on average, was 6.1% and 6.4%
in the two trials, compared with 1.3% and 1.2%. A third trial,
on obese people with Type 2 diabetes, showed similar
weight losses. Common side effects of the drug included
nausea and constipation. A few patients experienced more
serious complications, including gallbladder infection and
seizure.

Contrave's a combo of two drugs- naltrexone and
bupropion. Naltrexone has been used to lower cravings in
opioid addicts and alcoholics. It acts by blocking opioid
receptors in the brain. Bupropion, used in Wellbutrin and
Zyban, is an antidepressant and a anti-smoking aid.

High street chemists are selling a new over-the-counter diet
pill, Alli, to women who do not have weight problems. Trials
have showed that adding alli to a reduced-calorie, lower-fat
diet can help people to lose 50 per cent more fat than by
dieting alone. Alli aids weight loss by blocking absorption of
fat from food into the body. [2] Its side effects are relatively
"less dangerous" - oily stools, flatulence and vitamin
deficiency. The users for Alli are required to take
multivitamins.

Reference
[1] Contrave: New weight-loss hope? Los Angeles Times
July 22, 2009 [2] Miracle diet pill alli sold to slim women by
chemists Timesonline July 23, 2009