| ARRANON (NELARABINE) October 31, 2005 zhion@zhion.com |
Nelarabine (compound 506U78) is the water-soluble, 6-methoxy
analog of 9-beta-D-ara-G. Nelarabine is readily converted to
ara-G by endogenous adenosine deaminase. The half-life of
nelarabine is approximately 15 minutes compared with 2-4
hours for ara-G. The clearance of ara-G is higher in children
than in adults (0.312 vs 0.213 L x h(-1) x kg(-1)). Severe
myelosuppression was not consistently observed. Major
responses were seen in patients with T-cell malignancies.
Patients who responded had significantly higher intracellular
ara-GTP concentrations compared with those who did not
respond. [3.7,8]
This page is under construvtion
analog of 9-beta-D-ara-G. Nelarabine is readily converted to
ara-G by endogenous adenosine deaminase. The half-life of
nelarabine is approximately 15 minutes compared with 2-4
hours for ara-G. The clearance of ara-G is higher in children
than in adults (0.312 vs 0.213 L x h(-1) x kg(-1)). Severe
myelosuppression was not consistently observed. Major
responses were seen in patients with T-cell malignancies.
Patients who responded had significantly higher intracellular
ara-GTP concentrations compared with those who did not
respond. [3.7,8]
This page is under construvtion
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PHYTONUTRIENTS AND DRUG PRODUCTS. THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND DISEASES.
ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD CONSULT WITH YOUR
DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2008. DO NOT COPY NOR TRANSFER ARTICLES TO OTHER WEBSITES NOR OTHER
FORMS OF PUBLICATIONS. Privacy Policy. ARTICLE INDEX
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