Apokyn side effects
zhion@zhion.com November 2005
What is Apokyn used for?  

Apokyn is used by injection, as needed, only to treat loss of control of body
movements in people with advanced Parkinson' disease (PD). This condition is also
called hypomobility or episodes. An "off" episode may include symptoms such as
muscle stiffness, slow movements, and difficulty starting movements. Apokyn may
improve your ability to control your movements when it is used during an &episode.
This may help you walk, talk, or move around easier. Apokyn is not used to prevent
episodes. Apokyn does not take the place of your other medicines for PD.

Who should not take Apokyn?        

Do not take Apokyn if you are:

allergic to Apokyn or to any of its ingredients.  Apokyn contains a sulfite called
metabisulfite. Sulfites can cause severe, life-threatening allergic reactions in some
people, especially in people with asthma.
being treated with certain drugs to treat nausea and vomiting or irritable bowel
syndrome. These medications (including, for example, ondansetron, granisetron,
dolasetron, palonosetron, and alosetron) are called 5HT3 antagonists or blockers.
People taking this type of drug together with apomorphine have had severely low
blood pressure and lost consciousness or lacked out.?

Special Warning(s) with Apokyn:  

Apokyn should be injected just under the skin (subcutaneously), and not into a vein.

Carefully read the Apokyn instructions for Use" for complete instructions on
preparing and giving an injection of Apokyn.  Do not inject Apokyn unless you and
your caregiver have been taught the right way and both of you understand all the
directions. Ask your doctor or pharmacist if you have any questions.

General Precautions with Apokyn:

Do not drink alcohol or take medicines that make you sleepy while you are taking
Apokyn.

Do not drive a car, operate machinery, or do anything that might put you at risk of
getting

hurt until you know how Apokyn affects you. Apokyn may cause dizziness or fainting.   
Do not change your body position too fast. Get up slowly from sitting or lying. Apokyn
can lower your blood pressure and cause dizziness or fainting.  

What should I tell my health care provider?

Tell your health care provider if you:

have dizziness
have fainting spells
have low blood pressure
have asthma
are allergic to sulfites or sulfa medicines
have liver problems
have kidney problems
have heart problems
have had a stroke or other brain problems
have a mental problem called a major psychotic disorder
drink alcohol
are trying to become pregnant, are already pregnant, or are breast-feeding

Tell your health care provider about all the medicines you take, including prescription
and non-prescription medicines, vitamins, and herbal supplements.  Especially tell
your health care provider if you take: medicines to treat nausea, vomiting, or irritable
bowel syndrome including 5HT3 antagonists or blockers such as ondansteron
(Zofran), granisteron (Kytri)?, dolasteron (Anzemet), palonosteron (Aloxi)

vasodilators and other medicines that lower blood pressure

medicines that make you sleepy

What are some possible side effects of Apokyn? (This list is NOT a complete
list of side effects reported with Apokyn.  Your health care provider can discuss with
you a more complete list of side effects.)

Some common side effects with Apokyn include:

heart problems (shortness of breath, fast heartbeat, chest pain)

severe nausea and vomiting

sleepiness or falling asleep during the day  

falls

sudden uncontrolled movements

dizziness

hallucinations

depression

headache  

injection site reactions

swelling of arms/legs

increased sweating

flushing

paleness

yawning

runny nose

For more detailed information about Apokyn, ask your health care provider or
pharmacist.  
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