Xanthinol nicotinate
March 2009
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Marketers promote xanthinol nicotinate as an aid for muscle training and
weight loss, while animal studies suggest it may have health benefits of
blood pressure, lipid-lowering effects. It may also have benefits of memory
enhancement or ulcer recovering.

Thrombolytic and hypotensive actions of Xanthinol nicotinate in rats and on
its anti-platelet and fibrinolytic effects in patients with peripheral arterial
obliterative disease have been reported. [8] Xanthinol nicothinate may have
benefits of lipid-lowering activities. [3] Xanthinole nicotinate dilated perfused
vessels in a study of cats. [4] Xanthinol nicotinate was observed to lower the
blood pressure in dogs and monkeys. [6,7] Supplementation of 3 g/ day of
xanthinol nicotinate inhibited collagen-induced platelet aggregation in 24
male patients. [1]

Administration of 2400 mg of xanthinol nicotinate for 10 weeks was found to
promote healing of leg ulcers in a study of 16 patients suffered from multiple
leg ulcers. [2]

Xanthinol nicotinate was found to improve sensory register, short-term
memory and long-term memory in a study of 96 healthy subjects. Xanthinol
nicotinate inside the cell, might enhance cell metabolism and oxygen supply
in the brain. [5]

Side Effects

Low incidence of general itching and flushing was found in reference 2.

[1] Seidel G, Endell W. Effect of xanthinol nicotinate treatment on platelet
aggregation. Int J Clin Pharmacol Biopharm. 1977 Mar;15(3):139-43. [2] Afifi
AM, Adnan M, Taha M, Amasha ME. Xanthinol nicotinate in the management
of leg ulcers associated with haemoglobinopathies. Curr Med Res Opin.
1979;6(5):309-13. [3] Lipid-lowering effect of etofibrate, bezafibrate and
xanthinol nicotinate in patients with hyperlipoproteinemias Ther Ggw. 1982
May;121(5):301-11. [4] Gaevyĭ MD, Sankina TV, Nagornaia GV. Effect of
pentoxyfylline and xanthinol nicotinate on the overall blood pressure and
tonus of cerebral and peripheral vessels. Farmakol Toksikol. 1984 Jan-Feb;
47(1):53-7. [5] Loriaux SM, Deijen JB, Orlebeke JF, De Swart JH. The effects
of nicotinic acid and xanthinol nicotinate on human memory in different
categories of age. A double blind study. Psychopharmacology (Berl). 1985;
87(4):390-5. [6] Mungiu OC, Topoliceanu F, Ionescu GD. The action of
xanthinol nicotinate on the central and peripheral arterial pressure and on
respiration in dogs Rev Med Chir Soc Med Nat Iasi. 1991 Jul-Dec;95(3-4):
297-8. [7] Hegde KS, Selvamurthy W, Ray US, Patil SK. Role of xanthinol
nicotinate in the revival of monkeys subjected to acute haemorrhagic shock.
Indian J Med Res. 1991 Dec;94:440-6. [8] Bieroń K, Swies J, Kostka-Trabka
E, Gryglewski RJ. Thrombolytic and antiplatelet action of xanthinol nicotinate
(Sadamin): possible mechanisms. J Physiol Pharmacol. 1998 Jun;49(2):241-
9.