Hyaluronic Acid Foods
updated on November 12, 2011 zhion@zhion.com    
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Hyaluronic acid Quick View
Hyaluronic Acid is a polysaccharide composed of alternating molecules of N-acetyl glucosamine and D-glucuronic acid.
It can be found within collagen throughout the body. As the most important space filling substance in the human body.
Hyaluronic Acid holds water to keep collagen hydrated and "youthful". Now, what foods contain hyaluronic acid?
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Many online articles suggest that there are foods containing hyaluronic acid. One article titled "....herbs containing
hyaluronic acid
." But, its text says "there are no known herbs containing hyaluronic acid nor specific foods that contain
hyaluronic acid
!" The author suggests readers to eat more starchy foods to boost the body synthesis of hyaluronic
acid. If I follow his suggestion, I may raise up my triglyceride and body weight. While a popular website suggests the fish
oil and cod liver oil are sources of hyaluronic acid. However, if you check the labels of any fish oil / cod liver oil
supplements, you will find out that these supplements mainly contain fats and fatty acids. Anyway, without scientific
citations, soy, magnesium and zinc are mostly suggested to be helpful to boost the hyaluronic acid synthesis in our
body.
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According to
Wikipedia, hyaluronic acid is synthesized by a class of integral membrane proteins called hyaluronan
synthases, of which vertebrates have three types: HAS1, HAS2, and HAS3. These enzymes lengthen hyaluronan by
repeatedly adding glucuronic acid and N-acetylglucosamine to the nascent polysaccharide as it is extruded via ABC-
transporter through the cell membrane into the extracellular space. Further, Tammi R. and other colleagues found
hyaluronic acid content increases at the presence of retinoic acid (vitamin A). I would say, "intake of glucuronic acid, N-
acetylglucosamine and vitamin A" may boost the level of hyaluronic acid. Again, my hypothesis has no clinical support.

The food sources for glucuronic acid are Jerusalem artichokes and some other plants. While,  N-Acetylglucosamine
(GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit
of the polymer chitin. Chitin is present in arachnids, most fungal cell walls, insect exoskeletons, the shells of
crustaceans and parts of invertebrates. It is also present as an extracellular polymer of some microbes. [2] Since most
of us do not eat insect nor crab shells, we may simply obtain hyaluronic acid ingredients (monomers) or hyaluronic acid
from supplement-source.


[1] Tammi R, et al., Journal of Investigative Dermatology, 1989, 92: 326-332
[2] Jeen-Kuan Chen, et al, N-Acetylglucosamine: Production and Applications Mar Drugs. 2010; 8(9): 2493–2516.