Hyaluronic acid cream for Atopic Dermatitis
MAS063D is a hydrolipidic cream that has been developed for the management of atopic dermatitis. The putative
active ingredients of MAS063D are hyaluronic acid, telmesteine, Vitis vinifera, glycyrrhetinic acid. A five-week study in
30 adult patients with mild to moderate atopic dermatitis showed that MAS063D offered significant benefits over
placebo. MAS063D improved the total body area affected (17.2% --> 13.2%), itch score (2.7 --> 1.3 on a 10-point
scale) and EASI score (28.3 --> 24.3) after 22 days treatment compared to baseline. [6]

MAS063DP cream containing hyaluronic acid has received marketing authorization in the US and the European Union
for symptom relief of atopic dermatitis (eczema) and contact dermatitis. In a study, 218 patients self-administered
MAS063DP cream (N=145) or vehicle cream (N=73) 3 times per day to affected areas and those areas prone to be
affected. MAS063DP was statistically more effective than vehicle in all outcomes at all time points. The incidence of
rash was 2.1% in the MAS063DP group versus 5.5% in the vehicle group. Only 2 patients discontinued MAS063DP
due to adverse side effects.

The study concluded that the hyaluronic acid cream was confirmed to be a safe and effective treatment for mild to
moderate atopic dermatitis in adults. [8] A study of radiation dermatitis in patients receiving radiotherapy for breast
cancer also shows the effectiveness of this particular hyaluronic acid cream (MASO65D; Xclair) on for radiation
dermatitis and erythema. [9]

Hyaluronic Acid Cream for Wound Healing
Hyaluronic acid (hyaluronan) is a key component of the extracellular matrix and is known to be involved in several
mechanisms of the wound healing process. It has been shown to improve and accelerate the healing process of
chronic wounds. An open-label study shows that application of hyaluronic acid could also improve the healing
progression of acute wounds. [10] The following cases are reported in the past few years.

Oxygen free-radicals are known to impair wound healing after ischaemia-reperfusion or polymorphonuclear cell
stimulation. Male Sprague-Dawley rats with open wounds received phenazine methosulfate or zimosan, or had
abdominal sepsis to induce oxygen free-radical generation. Rats received hyaluronic acid cream, hyaluronic acid ethyl
ester gel, or placebo treatment. Hyaluronic acid and its ethyl ester derivative significantly improved the wound healing
of rats subjected to an increased generation of oxygen free-radicals. [1]

Hyaluronic acid protects granulation tissue from oxygen free radical damage and stimulates wound healing, but the
regular molecular weight of hyaluronic acid prevents it from permeating the epidermal barrier. A low molecular weight
hyaluronic acid preparation is able to permeate the skin. A study was conducted in rats with excisional or incisional
wounds. Wound contraction over 11 days and breaking strength on the fifth day were measured. Oxygen free radical
production was induced. The wounds were treated topically with low molecular weight hyaluronic acid (0.2%) cream or
placebo.
Wound healing was significantly slower in the xenobiotic group than in the control groups. These effects were strongly
reduced by topical administration of low molecular weight hyaluronic acid (0.2%) cream and in incisional wounds by
topically injected superoxide dismutase. Low molecular weight hyaluronic acid is effective as the native compound
against oxygen free radicals. [4]

The effect of hyaluronic acid (Ialugen cream) on acute skin reactions after radiotherapy, was assessed in a
randomized, double-blind, placebo-controlled study. Out of the 152 patients presenting with head and neck, breast or
pelvic carcinomas and registered in the study, 134 cases-70 in the Ialugen group (IA) and 64 in the placebo group
(PBO)-completed their IA or PBO treatment. The mean total dose of radiation given during the study was 60.6 +/- 10.9
Gy in the IA group and 64.3 +/- 10.8 Gy in the PBO group (P = 0.47). The prophylactic use of a cream with hyaluronic
acid is shown to reduce the incidence of high grade radio-epithelitis, suggesting an interesting role of the hyaluronic
acid cream as supportive treatment to improve compliance and quality of life in patients undergoing radiation therapy.
[2]

Silver sulfadiazine has been the gold standard for topical burn therapy. The addition to it of hyaluronic acid, which
forms a substantial part of the human tissue intercellular matrix, is aimed at overcoming one of its very few
disadvantages, i.e. prolongation of the wound re-epithelialization process. A cream formulation containing hyaluronic
acid and silver sulfadiazine was found to have favorable antibacterial, anti-edematous and local analgesic effects,
together with a clear stimulatory activity on the re-epithelialization process. [5] Connettivina Plus cream contains 0.2%
hyaluronic acid and 1% silver sulfadiazine (SSD). In a study of treatment of second-degree burns, the SSD /
hyaluronic acid cream works better than SSD does alone. SSD-hyaluronic acid cream caused a significantly more
rapid re-epithelialization of burns, i.e. a shorter time to healing, than SSD alone. [7] Application of combest combinated
with bioglass and hyaluronan has been reported to be ibeneficial to the proliferation of the granulation and wound
healing with good safety for wounds classified as deep degrees II. [12]

For wrinkles and other topical applications, please, review:
HYALURONIC ACID TOPICAL PRODUCTS
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Hyaluronic Acid Cream
updated on October 20, 2011 zhion@zhion.com    
Reasonable care has been taken in preparing this document and the information provided herein is believed to be
accurate. The information is not intended to be a substitute for professional medical advice. It is important to seek the
advice of a physician about any medical condition or symptom or the benefits and side effects of a supplement or a
drug product. Finally, please, do not transfer the article to other website. Thank you. ALL RIGHTS RESERVED.
Hyaluronic acid Quick View
Hyaluronic Acid is a polysaccharide composed of alternating molecules of N-acetyl glucosamine and D-glucuronic
acid. It can be found within collagen throughout the body. As the most important space filling substance in the human
body. Hyaluronic Acid holds water to keep collagen hydrated and "youthful". Hyaluronic Acid forms a viscous fluid with
exceptional lubricating properties necessary for the vital functions of many parts of the human body including the skin,
heart valves, aqueous/ vitreous humor of the eye and synovial fluid (joint lubricant). In the past, because of its large
molecular weight, the absorption for Hyaluronic Acid in the digestive tract was almost impossible. However, an
enzyme-cleaving technique has been developed to break down Hyaluronic Acid into lower molecular weight polymers.
This allows easy absorption of Hyaluronic Acid when taken orally. Now, does a hyaluronic acid cream work topically?
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