Scientific Evidence for The Effectiveness of Hyaluronic Acid Topical Products
The hyaluronic acid topical products may be applied for local treatments such as dermatitis, wound healing and
wrinkles. Mostly, hyaluronic acid is blended with other active ingredients in the topical products. Here is a summary of
scientific studies:

Skin - Atopic Dermatitis and Wound Healing
MAS063D is a hydrolipidic hyaluronic acid cream that has been developed for the management of atopic dermatitis.
The putative active ingredients of MAS063D are hyaluronic acid, telmesteine, Vitis vinifera, glycyrrhetinic acid. A
five-week study in 30 adult patients with mild to moderate atopic dermatitis showed that MAS063D offered significant
benefits over placebo.
HYALURONIC ACID CREAM.

Skin - Wrinkles and Appearance
A study was conducted to observe the efficacy of topical application of 0.1% hyaluronan (a hyaluronic acid)
formulations of different molecular weights (MW) (50, 130, 300, 800 and 2000 kDa, respectively) in the periocular area
as anti-wrinkle treatment. Measurements of wrinkle depth using mean roughness (Ra) and maximum roughness (Rz)
values revealed significant improvement in the 130 and the 50 kDa HA group after 60 days of treatment compared to
placebo-treated area.
HYALURONIC ACID TOPICAL PRODUCTS
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Skin Care - Hyaluronic acid
November 09, 2011 zhion@zhion.com    
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Hyaluronic acid Quick View
Hyaluronic Acid is a polysaccharide composed of alternating molecules of N-acetyl glucosamine and D-glucuronic acid. It
can be found within collagen throughout the body. As the most important space filling substance in the human body.
Hyaluronic Acid holds water to keep collagen hydrated and "youthful". Hyaluronic Acid forms a viscous fluid with
exceptional lubricating properties necessary for the vital functions of many parts of the human body including the skin,
heart valves, aqueous/ vitreous humor of the eye and synovial fluid (joint lubricant). The skin contains over 50% of the
bodies Hyaluronic Acid. Considering that skin is over 70% water and renews itself more readily than most other bodily
tissues. Definitely hyaluronic Acid may have benefits on skin's structure and daily maintenance.

In the past, because of its large molecular weight, the absorption for Hyaluronic Acid in the digestive tract was almost
impossible. However, an enzyme-cleaving technique has been developed to break down Hyaluronic Acid into lower
molecular weight polymers. This allows easy absorption of Hyaluronic Acid when taken orally.
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The main function of the skin is to protect the body against environmental substances and excessive water loss. The
skin barrier, stratum corneum, locates at the outermost layer of the skin, which is composed of corneocytes, embedded
in organized complex lipid domains. In the process of epidermal renewal, keratinocytes arrive at the outermost layer of
the epidermis, the horny layer, the keratinocytes become corneocytes, anucleated flattened cells, filled with keratin.
This is a water insoluble protein accounting for 95% of all proteins present in the epidermis, and contributes the
protective function of skin.

Moisturizing of the skin is considered as the first anti-aging skin care. It is because skin moisturization is essential for its
appearance, protection, complexion, softness and the reinforcement of its barrier properties against hostile
environmental factors. The intrinsic water binding capacity of skin is not only due to the complex natural moisturizing
factor present in dead cells, but also to
hyaluronic acid and a regulated water transport within the skin. Aquaporins,
dedicated water and glycerol transport proteins, controls the water movements between the cells at the different levels
of the epidermis. Other factors contributing to skin moisturization include corneodesmosomes and tight junctions. The
cornedoesomosomes are "rivets" that hold the corneocytes together. Tight junctions are multiprotein complexes that
allow cell-cell adhesion. Water and pH are also important factors in the regulation of the epidermal enzymes linked to
corneocytes desquamation and lipid synthesis. [Bonté F., Skin moisturization mechanisms: new data. Ann Pharm Fr.
2011 May;69(3):135-41.]
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