The Danger of Sucralose - the key ingredient of
Splenda
Splenda
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Discuss with your doctor before taking any alternative medicine. This article is for
reference only, it is not a medical advice. All rights reserved. Do not copy this article to
other website or blog.
reference only, it is not a medical advice. All rights reserved. Do not copy this article to
other website or blog.
Sucralose (trichlorogalactosucrose, a unique disaccharide, a key ingredient of
Splenda) is an artificial sweetener from native sucrose that was approved by the
FDA on April 1, 1998 (April Fool's Day).
Side Effect of Sucralose
Patel RM and co-workers from Mercer University School of Medicine, Macon, GA,
ported a potential association between sucralose and migraines. [1] Bigal ME and
Krymchantowski AV from The Albert Einstein College of Medicine. NY, reported a
patient with attacks of migraine consistently triggered by sucralose. She also suffers
from menstrually related migraine that had been well-controlled for several months
since she switched her contraceptive from fixed estrogen to triphasic contraceptive
pills. Some attacks triggered by sucralose were preceded by aura, and she had
never experienced migraine with aura before. Withdrawal of the compound was
associated with complete resolution of the attacks. [2]
Goldsmith LA from McNeil Specialty Products Company published a paper titled, "
Acute and subchronic toxicity of sucralose" in Food Chem Toxicol. in 2000 and he
claimed that he observed no toxicologically significant effects at the 1.0% or 2.5%
dietary levels of sucralose for 4 and 8 weeks in male and female mice. [4] What
happens if an animal takes it daily for a year or longer?
A 52 week-study of rats showed that sucralose was not carcinogenic. Sucralose did
not adversely affect the survival or clinical condition of the rats, and there were no
toxicologically significant findings. However, adverse or side effects were noticed in
the sucralose treated female groups especially at higher doses. The adverse
findings included renal pelvic epithelial hyperplasia, renal pelvic mineralization and
adrenal cortical haemorrhagic degeneration. While, cataracts were found in male
rats at high doses. [3]
Reference:
[1] Patel RM, Sarma R, Grimsley E. Popular sweetner sucralose as a migraine trigger.
Headache. 2006 Sep;46(8):1303-4. [2] Bigal ME, Krymchantowski AV. Migraine
triggered by sucralose--a case report. Headache. 2006 Mar;46(3):515-7. [3] Mann
SW, Yuschak MM, Amyes SJ, Aughton P, Finn JP. A combined chronic toxicity /
carcinogenicity study of sucralose in Sprague-Dawley rats. Food Chem Toxicol.
2000;38 Suppl 2:S71-89. [4] Goldsmith LA. Acute and subchronic toxicity of
sucralose. Food Chem Toxicol. 2000;38 Suppl 2:S53-69.
Splenda) is an artificial sweetener from native sucrose that was approved by the
FDA on April 1, 1998 (April Fool's Day).
Side Effect of Sucralose
Patel RM and co-workers from Mercer University School of Medicine, Macon, GA,
ported a potential association between sucralose and migraines. [1] Bigal ME and
Krymchantowski AV from The Albert Einstein College of Medicine. NY, reported a
patient with attacks of migraine consistently triggered by sucralose. She also suffers
from menstrually related migraine that had been well-controlled for several months
since she switched her contraceptive from fixed estrogen to triphasic contraceptive
pills. Some attacks triggered by sucralose were preceded by aura, and she had
never experienced migraine with aura before. Withdrawal of the compound was
associated with complete resolution of the attacks. [2]
Goldsmith LA from McNeil Specialty Products Company published a paper titled, "
Acute and subchronic toxicity of sucralose" in Food Chem Toxicol. in 2000 and he
claimed that he observed no toxicologically significant effects at the 1.0% or 2.5%
dietary levels of sucralose for 4 and 8 weeks in male and female mice. [4] What
happens if an animal takes it daily for a year or longer?
A 52 week-study of rats showed that sucralose was not carcinogenic. Sucralose did
not adversely affect the survival or clinical condition of the rats, and there were no
toxicologically significant findings. However, adverse or side effects were noticed in
the sucralose treated female groups especially at higher doses. The adverse
findings included renal pelvic epithelial hyperplasia, renal pelvic mineralization and
adrenal cortical haemorrhagic degeneration. While, cataracts were found in male
rats at high doses. [3]
Reference:
[1] Patel RM, Sarma R, Grimsley E. Popular sweetner sucralose as a migraine trigger.
Headache. 2006 Sep;46(8):1303-4. [2] Bigal ME, Krymchantowski AV. Migraine
triggered by sucralose--a case report. Headache. 2006 Mar;46(3):515-7. [3] Mann
SW, Yuschak MM, Amyes SJ, Aughton P, Finn JP. A combined chronic toxicity /
carcinogenicity study of sucralose in Sprague-Dawley rats. Food Chem Toxicol.
2000;38 Suppl 2:S71-89. [4] Goldsmith LA. Acute and subchronic toxicity of
sucralose. Food Chem Toxicol. 2000;38 Suppl 2:S53-69.