How does fructose screw up our health?
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How does fructose screw up our health?

Suzy Cohen, a writer at Tulsa World, points out that "high fructose corn syrup"
is a very concentrated sweetener that forces your pancreas to secrete a
truckload of insulin in order to neutralize the blood sugar spike that occurs after
consumption. High insulin blood levels increase risk of many diseases, including
pancreatic cancer and diabetes. [3, 4] Fructose is only metabolized in the liver,
not taken up and utilized by all body cells like glucose. This creates a problem
for the liver. After prolonged high intake of fructose, the liver becomes fatty and
scarred - cirrhosis. In fact, fructose can be found in root vegetables and many
fruits, such as tree fruits and berries. [4]

A study of 74 men in Spain with an average age of 51 suggested that a diet
high in fructose raises blood pressure among men. After two weeks, the
subjects had an increase of 6 mm Hg in their systolic blood pressure and a
3-mm Hg rise in their diastolic blood pressure. The effect seemed to be
reversible; most of the elevated blood pressure readings returned to normal
after two months. [1,2]

Why has excess fructose consumption been hypothesized to be a contributing
cause of insulin resistance, obesity, elevated LDL cholestrol and triglycerdes?

Most of the carbohydrates we eat are made up of chains of glucose. When
glucose enters the bloodstream, the body releases insulin to help regulate it.
Fructose, on the other hand, is processed in the liver. When too much fructose
enters the liver, the liver starts making fats from the fructose and sending them
off into the bloodstream as triglycerides. [about.com]

High fructose consumption can lead to excess pyruvate production, causing a
buildup of Krebs cycle intermediates. Accumulated citrate can be transported
from the mitochondria into the cytosol of hepatocytes for fatty acid synthesis; it
provides the glycerol backbone for the triglyceride molecule. Triglycerides are
incorporated into very low density lipoproteins (VLDL), which are released from
the liver destined toward peripheral tissues for storage in both fat and muscle
cells. [Wikipeidia]

[1] Fructose linked to high blood pressure Saturday Sept 26, 2009
(foodconsumer.org) [2] Nicole Ostrow High-Fructose Diet Raises Blood Pressure
in Middle-Aged Men Sept. 23 (Bloomberg) [3] Suzy Cohen, Six ways to protect
yourself against aggressive pancreatic cancer, www.tulsaworld.com, 9/19/2009  
2:30 AM [4] Robert Schneider, M.D., Fructose, stevia, agave, acai, pomegranate,
hoodia. Are they good for you?  Examiner.com, September 2, 3:44 PM